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RK-682 (calcium salt)

RK-682 (calcium salt)

产品编号 T36367   CAS 332131-32-5

Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the PTPs. It inhibits the phosphorylation of CD45 and VHR with IC50 values of 54 and 2 μM, respectively, and arrests cell cycle progress at the G1/S transition. It is also reported to inhibit heparanase (IC50 = 17 μM), an endo-β-D-glucuronidase involved in tumor cell invasion and angiogenesis. RK-682 (calcium salt) is a less soluble version of the free acid.

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RK-682 (calcium salt) Chemical Structure
RK-682 (calcium salt), CAS 332131-32-5
规格 价格/CNY 货期 数量
500 μg ¥ 4,230 35日内发货
其他形式的 RK-682 (calcium salt):
药物设计专题培训
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
产品目录号及名称: RK-682 (calcium salt) (T36367)
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存储 & 溶解度
产品描述 Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the PTPs. It inhibits the phosphorylation of CD45 and VHR with IC50 values of 54 and 2 μM, respectively, and arrests cell cycle progress at the G1/S transition. It is also reported to inhibit heparanase (IC50 = 17 μM), an endo-β-D-glucuronidase involved in tumor cell invasion and angiogenesis. RK-682 (calcium salt) is a less soluble version of the free acid.
分子量 779.122
分子式 C42H74CaO10
CAS No. 332131-32-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Methanol: Soluble

Ethanol: Soluble

DMF: Soluble

DMSO: Soluble

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Keywords

RK-682 (calcium salt) 332131-32-5 RK682 (calcium salt) RK-682 RK 682 RK682 RK 682 (calcium salt) Inhibitor inhibitor inhibit

 

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