规格

价格

库存

数量

1 mg

¥ 970

现货

2 mg

¥ 1,480

现货

5 mg

¥ 2,950

现货

10 mg

¥ 4,350

现货

25 mg

¥ 6,960

现货

50 mg

¥ 9,390

现货

100 mg

¥ 12,600

现货

1 mL x 10 mM (in DMSO)

¥ 2,920

现货

生物活性

产品描述	KPT-6566 is a novel selective covalent pin1 inhibitor, KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain,and has anti-cancer activity.
靶点活性	PIN1 PPIase:640 nM
体外活性	KPT-6566与PIN1的催化位点形成共价结合，抑制了PIN1的PPIase活性，并显示出0.64μM的IC50值。这种相互作用导致释放类醌药物，产生活性氧物种和DNA损伤，特异性地诱导癌细胞死亡。
细胞实验	For IC50 determination, human recombinant PIN1 was preincubated with different concentrations of KPT-6566 and PPIase activity was measured after 180 min. K values of PPIase activity were plotted against inhibitor concentration in a semi-logarithmic plot.
别名	2-[[4-[[[4-(叔丁基)苯基]磺酰基]亚氨基]-1-氧代-1,4-二氢-2-萘基]硫基]乙酸

化学信息

分子量	443.54
分子式	C₂₂H₂₁NO₅S₂
CAS No.	881487-77-0
Smiles	CC(C)(C)c1ccc(cc1)S(=O)(=O)\N=C1/C=C(SCC(O)=O)C(=O)c2ccccc12
密度	1.32 g/cm3 (Predicted)
颜色	Yellow
物理性状	solid

储存&溶解度

存储

store at low temperature,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 120 mg/mL (270.55 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Saline: 1 mg/mL (2.25 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2546 mL	11.2729 mL	22.5459 mL	112.7294 mL
5 mM	0.4509 mL	2.2546 mL	4.5092 mL	22.5459 mL
10 mM	0.2255 mL	1.1273 mL	2.2546 mL	11.2729 mL
20 mM	0.1127 mL	0.5636 mL	1.1273 mL	5.6365 mL
50 mM	0.0451 mL	0.2255 mL	0.4509 mL	2.2546 mL
100 mM	0.0225 mL	0.1127 mL	0.2255 mL	1.1273 mL