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S6K-18

Name: S6K-18
Brand: TargetMol
SKU: T22422
Price: 357 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.99%

货号 T22422Cas号 1265789-88-5

S6K-18 是一种高度选择性的 S6K1 抑制剂，抑制 S6K1，IC50 为 52nM。

为众多的药物研发团队赋能，

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S6K-18

一键复制产品信息

很棒

纯度: 98.99%

货号 T22422Cas号 1265789-88-5

S6K-18 是一种高度选择性的 S6K1 抑制剂，抑制 S6K1，IC50 为 52nM。

规格	价格	库存
1 mg	¥ 357	现货
5 mg	¥ 893	现货
10 mg	¥ 1,530	现货
25 mg	¥ 2,620	现货
50 mg	¥ 3,750	现货
100 mg	¥ 5,130	现货
200 mg	¥ 6,930	现货
1 mL x 10 mM (in DMSO)	¥ 972	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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常见问题解答

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纯度: 98.99%

颜色: 白色

性状: Solid

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资源下载:

COA LCMS HNMR HPLC 产品操作手册

产品介绍

S6K-18 AI Summary

S6K-18 exhibits a broad spectrum of bioactivities, particularly as a kinase inhibitor with selective targets and favorable pharmacokinetic properties. It inhibits S6K1 with an IC50 of 52 µM and demonstrates varying degrees of inhibition on kinases such as ROCK1, MARK1, EPHA2, CSNK1D, CHEK1, PRKCB, and CAMK1 at concentrations of 10 µM and 1 µM. Additionally, it strongly inhibits RPS6KB1 at these concentrations. The compound shows moderate inhibition on CYP2C9 and CYP1A2 at 3 µM based on LC/MS/MS analysis, while it does not significantly inhibit CYP3A4 and CYP2D6 or displace labeled dofetilide in other assays. Human liver microsome studies reveal a favorable half-life, and PAMPA analysis indicates moderate permeability. S6K-18 also demonstrates significant antiproliferative effects across various cell lines, including HBL1, hMSC, TMD8, and ED40515 IL2-dependent ATL cells, with potencies ranging from 0.08333 nM to 20931.0 nM. It effectively inhibits the proliferation of Plasmodium falciparum in different strains with potencies from 0.7 nM to 21117.7 nM and displays gametocytocidal activity at 16626.1 nM. Moreover, it shows efficacy in immunotoxin sensitization and mitigation studies with a potency of 3.7 nM. These characteristics position S6K-18 as a promising candidate for further development as a selective kinase inhibitor and antiproliferative agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.
靶点活性	p70 S6K1:52 nM

化学信息

分子量	358.41
分子式	C₁₇H₁₈N₄O₃S
CAS No.	1265789-88-5
Smiles	CC(C)(C)c1cc(C(O)=O)c(NC(=O)Nc2ccc3[nH]ncc3c2)s1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 3.59 mg/mL (10.02 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7901 mL	13.9505 mL	27.9010 mL	139.5050 mL
5 mM	0.5580 mL	2.7901 mL	5.5802 mL	27.9010 mL
10 mM	0.2790 mL	1.3951 mL	2.7901 mL	13.9505 mL

计算器

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。