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上市药物库

上市药物库

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产品编号 L1000 Approved Drug Library
  库化合物信息   Excel SDF

传统的药物开发涉及从头确认和验证新分子实体,这是一个耗时且成本高昂的过程,随着对药物安全性及有效性的要求不断提高,开发新药的成本还将持续上涨。由于时间和成本大幅降低,近年来药物功能重定位受到越来越多关注,高内涵筛选、新的生物标志物发现和生物信息学的快速发展为基于靶点或细胞的药物重定位创造了机会。

上市药物都具有已知的和良好表征的生物活性、安全性和生物利用度,这些特征可以显著加速药物开发和优化,从上市药物中筛出的苗头化合物将为后续的药物优化计划提供有利的线索。

此外,由于活性明确,靶点已知,很多科学家会从上市药物库中选择可以用于细胞诱导分化的小分子,通过单一或几个小分子的联合作用,选择出将各种体细胞诱导成为诱导多能干细胞、神经前体细胞、心肌细胞等,甚至还有使用小分子组合在体内完成诱导分化的成功尝试。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
规格
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
如果上述化合物库无法满足您的需求,您可发送邮件至tech@targetmol.com咨询我们的技术专员,为您量身定制专属化合物库!
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产品描述

  • 2863个上市药物化合物集合,可用于高通量筛选和高内涵筛选;
  • 所有化合物得到FDA、EMA、NMPA等权威部门审批;
  • 老药新用、新的药物靶点筛选的有效工具;
  • 涵盖多个研究领域:肿瘤、心血管药物、抗炎/免疫、神经系统药物、呼吸系统药物等;
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • 结构多样,药效显著,可渗透细胞;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

化合物库定制

TargetMol的化合物可以高度定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L1000)
点击图片重新获取验证码

客户使用化合物库发表的文献

1. Nature. 2020, 582: 289-293. 2. Nucleic Acids Research. 2021. 3. Nature Communications. 2023, 14(1): 7574. 4. Protein & Cell. 2021, 12(11): 877-888. 5. Nature Communications. 2021, 12(1): 1-12. 6. Cell Reports. 2022: 111117. 7. Cancer Letters. 2022: 216011. 8. Cell Death & Disease. 2023, 14(1): 11. 9. Cell & Bioscience. 2022, 12(1): 1-17.
10. Cell Reports. 2022, 39(1): 110643. 11. Pharmacological Research. 2021: 105860. 12. Acta Pharmacologica Sinica. 2023: 1-14. 13. Elife. 2021, 10: e63810. 14. Mbio. 2021, 12(1): e02754-20. 15. European Journal of Medicinal Chemistry. 2023: 115893. 16. Elife. 2021, 10: e67381. 17. Communications Biology. 2022, 5(1): 1-13. 18. Molecular Cancer Therapeutics. 2018 Feb;17(2):419-431. 19. Computational and Structural Biotechnology Journal. 2022. 20. iScience. 2023. 21. Frontiers in chemistry. 2022, 10. 22. Bioorganic Chemistry. 2022: 106191. 23. Frontiers in Cellular and Infection Microbiology. 2021: 1280. 24. Bioorganic Chemistry. 2020. 25. Scientific Reports. 2022, 12(1): 1-16. 26. Methods. 2022, 205: 247-262. 27. Cancer Science. 2021, 112(11): 4722. 28. Cognitive computation. 2021 Feb 2;1-13. 29. Antiviral Research. 2020, 174: 104701. 30. Toxicology and Applied Pharmacology. 2023: 116792. 31. Virology. 2022. 32. Investigational New Drugs. 2019 May 14: 1-10. 33. Acta Biochimica et Biophysica Sinica. 2021. 34. Structural Chemistry. 2022: 1-13. 35. Chinese Medical Journal. 2020, 133(9): 1051-1056. 36. Interdisciplinary Sciences, Computational Life Sciences. 2020, 12: 368-376. 37. Researchsquare. 2023. 38. BVS. 2020. 39. Journal of Southern Medical University. 2022, 42(4): 554-560. 40. Journal of Southern Medical University. 2021, 41(12): 1835-1842. 41. Strategies to Overcome Superbug Invasions. 2021: 269-287. 42. bioRxiv. 2020. 43. Research square. 2020. 44. Researchsquare. 2020. 45. Cell Stem Cell. 2022 Apr 29(4) 545–558. 46. Science Bulletin. 2022. 47. Science Translational Medicine. 2022, 14(656): eabn3231. 48. Science Advances. 2023, 9(9): eade3760. 49. Nature Biotechnology. 2021, 39(11): 1444-1452. 50. Nature Communications. 2022, 13(1): 1-15..
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化合物库组成

Antibacterial (411)
Antibiotic (385)
Autophagy (341)
Endogenous Metabolite (256)
Apoptosis (251)
5-HT Receptor (165)
Adrenergic Receptor (161)
AChR (140)
COX (120)
Dopamine Receptor (112)
Histamine Receptor (109)
Parasite (93)
Antifungal (90)
HIV Protease (87)
DNA/RNA Synthesis (83)
Sodium Channel (80)
Calcium Channel (78)
Potassium Channel (75)
Glucocorticoid Receptor (54)
Topoisomerase (54)
Estrogen/progestogen Receptor (48)
Ferroptosis (47)
PDE (45)
Influenza Virus (44)
P450 (44)
SARS-CoV (42)
Reactive Oxygen Species (39)
RAAS (39)
NF-κB (38)
EGFR (37)
GABA Receptor (35)
Dehydrogenase (34)
ribosome (34)
VEGFR (32)
Mitophagy (32)
c-Kit (32)
Nucleoside Antimetabolite/Analog (30)
HCV Protease (30)
Serotonin Transporter (30)
PPAR (29)
PDGFR (29)
Prostaglandin Receptor (28)
AChE (28)
Estrogen Receptor/ERR (26)
HSV (26)
Microtubule Associated (26)
Reverse Transcriptase (26)
Norepinephrine (25)
Proteasome (24)
Progesterone Receptor (23)
Antifection (22)
DNA Alkylator/Crosslinker (22)
HBV (22)
Proton pump (22)
MAO (22)
ATPase (21)
iGluR (20)
Androgen Receptor (19)
Carbonic Anhydrase (19)
Opioid Receptor (19)
JAK (19)
Virus Protease (18)
HDAC (18)
Thrombin (17)
FLT (17)
Monoamine Oxidase (16)
ROS (16)
TNF (16)
FGFR (16)
Tyrosine Kinases (15)
Bcr-Abl (15)
DPP-4 (15)
Src (15)
c-Met/HGFR (15)
Adenosine Receptor (15)
Transferase (14)
Phosphatase (14)
MRP (14)
TRP/TRPV Channel (14)
PKC (13)
NMDAR (13)
HIF/HIF Prolyl-Hydroxylase (13)
Antifolate (13)
Drug Metabolite (12)
Raf (12)
CDK (12)
Retinoid Receptor (12)
ALK (11)
HMG-CoA Reductase (11)
P-gp (11)
Phospholipase (11)
DNA gyrase (11)
DHFR (11)
GluR (11)
IL Receptor (11)
SGLT (11)
Amino Acids and Derivatives (11)
Thyroid hormone receptor(THR) (11)
Lipoxygenase (10)
MMP (10)
CaMK (10)
c-RET (10)
DNA Alkylation (10)
PARP (10)
Mitochondrial Metabolism (9)
PI3K (9)
ABC (9)
Factor Xa (9)
BTK (9)
AMPK (9)
Interleukin (9)
CAT (8)
Antiviral (8)
Tyrosinase (8)
Antioxidant (8)
mTOR (8)
NO Synthase (8)
P2Y Receptor (8)
Trk receptor (7)
Monoamine Transporter (7)
GNRH Receptor (7)
Vasopressin Receptor (7)
Neurokinin receptor (7)
DNA Methyltransferase (7)
Beta Amyloid (7)
GPR (7)
MEK (7)
NADPH (7)
Nrf2 (7)
S1P Receptor (7)
STAT (7)
HER (7)
CFTR (7)
Chloride channel (7)
DNA (6)
Serine Protease (6)
Histone Methyltransferase (6)
Glutathione Peroxidase (6)
LPL Receptor (6)
ERK (6)
Endothelin Receptor (6)
Aromatase (6)
Hedgehog/Smoothened (6)
PKA (6)
BCL (6)
TAM Receptor (6)
Xanthine Oxidase (5)
Guanylate cyclase (5)
Reductase (5)
TLR (5)
Anti-infection (5)
ROCK (5)
Sigma receptor (5)
ROS Kinase (5)
Hydroxylase (5)
P2X Receptor (5)
Akt (5)
CaSR (5)
Caspase (5)
Ras (5)
Cysteine Protease (5)
FXR (5)
Wnt/beta-catenin (5)
Integrin (5)
Fatty Acid Synthase (5)
Leukotriene Receptor (5)
Cell wall (4)
Aryl Hydrocarbon Receptor (4)
HSP (4)
PGE Synthase (4)
AhR (4)
HIF (4)
Lipid (4)
p38 MAPK (4)
Oxytocin Receptor (4)
MT Receptor (4)
Neprilysin (4)
NOS (4)
Smo (4)
IκB/IKK (4)
Ligand for E3 Ligase (4)
Annexin A (4)
NOD (4)
Decarboxylase (4)
Molecular Glues (4)
LTR (4)
UGT (4)
Melatonin Receptor (4)
GPCR19 (4)
GSK-3 (4)
NOD-like Receptor (NLR) (3)
GST (3)
Aminopeptidase (3)
c-Fms (3)
Free radical scavengers (3)
Imidazoline Receptor (3)
Gamma-secretase (3)
Glucosidase (3)
TOPK (3)
Histone Demethylase (3)
Cannabinoid Receptor (3)
Serine/threonin kinase (3)
Na-K-Cl cotransporter (3)
Isocitrate Dehydrogenase (IDH) (3)
cholecystokinin (3)
PAK (3)
CCR (3)
FAK (3)
Syk (3)
Complement System (3)
IGF-1R (3)
LDL (3)
Glutathione reductase (3)
Arginase (3)
TGF-beta/Smad (3)
Gap Junction Protein (3)
Adenosine deaminase (3)
Monocarboxylate transporter (2)
ROR (2)
CGRP Receptor (2)
Melanocortin Receptor (2)
Ligands for Target Protein for PROTAC (2)
PKM (2)
YAP (2)
GHSR (2)
CRM1 (2)
Protease-activated Receptor (2)
PLK (2)
OAT (2)
Hexokinase (2)
GlyT (2)
Phosphorylase (2)
CETP (2)
Integrase (2)
Thrombopoietin Receptor (2)
Beta-Secretase (2)
MAPK (2)
Acyltransferase (2)
Rho (2)
Aurora Kinase (2)
IRE1 (2)
Ephrin Receptor (2)
CXCR (2)
GluCls (2)
IFNAR (2)
RSV (2)
FAAH (1)
S6 Kinase (1)
Bradykinin Receptor (1)
PROTAC Linker (1)
Angiotensin-converting Enzyme (ACE) (1)
Hck (1)
Na+/Ca2+ Exchanger (1)
Glucagon Receptor (1)
Taste receptor (1)
Liver X Receptor (1)
Mdm2 (1)
NPC1L1 (1)
GRK (1)
MTH1 (1)
PAFR (1)
Adiponectin receptor (1)
p53 (1)
PD-1/PD-L1 (1)
Myosin (1)
Immunology/Inflammation related (1)
advanced glycation end products (1)
NADPH-oxidase (1)
PAD (1)
OX Receptor (1)
Telomerase (1)
Pyroptosis (1)
Histone Acetyltransferase (1)
CRISPR/Cas9 (1)
Sirtuin (1)
STING (1)
PDK (1)
RAR/RXR  (1)
IAP (1)
Lipase (1)
Aquaporin (1)
ATP Citrate Lyase (1)
JNK (1)
gp120/CD4 (1)
Chk (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
DUB (1)
VDA (1)
Dynamin (1)
Epigenetic Reader Domain (1)
DNA-PK (1)
cAMP (1)
ACK (1)
Epoxide Hydrolase (1)
BACE (1)
Platelet aggregation (1)
Hydrogenase (1)
Somatostatin (1)
CSF-1R (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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