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Cdk2 Inhibitor II

Name: Cdk2 Inhibitor II
Brand: TargetMol
SKU: T36933
Price: 1980 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.27%

货号 T36933Cas号 222035-13-4

别名 CDK2-IN-3, Cdk2 Inhibitor II

Cdk2 Inhibitor II 是一种具有选择性和有效性的 CDK2 抑制剂，50 为 60 nM。

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Cdk2 Inhibitor II

一键复制产品信息

很棒

纯度: 97.27%

货号 T36933 别名 CDK2-IN-3, Cdk2 Inhibitor IICas号 222035-13-4

Cdk2 Inhibitor II 是一种具有选择性和有效性的 CDK2 抑制剂，50 为 60 nM。

规格	价格	库存
1 mg	¥ 1,980	现货
5 mg	¥ 3,790	现货
10 mg	¥ 5,430	现货
25 mg	¥ 8,160	现货
50 mg	¥ 10,800	现货
100 mg	¥ 14,800	现货
200 mg	¥ 19,600	现货

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实验操作小课堂

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选择批次:

纯度: 97.27%

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COA LCMS HNMR 产品操作手册

产品介绍

Cdk2 Inhibitor II AI Summary

Cdk2 Inhibitor II exhibits significant bioactivity as an inhibitor of multiple cyclin-dependent kinases (CDKs), with a particularly strong effect on CDK2, showing an IC50 of 60.0 nM. It also inhibits CDK1 with an IC50 of 780.0 nM. The compound demonstrates activity against several other CDKs including CDK4, CDK5, CDK7, and CDK9, suggesting broad inhibitory potential across different cyclin-dependent kinases, which contributes to inducing cell cycle arrest in the G2/M phase in human HCT116 cells. Additionally, Cdk2 Inhibitor II shows inhibitory activity against various isoforms of human carbonic anhydrase, notably achieving a Ki value of 24.8 nM against carbonic anhydrase 9, indicating a high degree of selectivity. The compound's protective effects against cisplatin-induced toxicity have been observed in mouse cochlear explants and neonatal mouse HEI-OC1 cells, with EC50 values of 1000.0 nM and 127.0 nM, respectively, demonstrating its potential therapeutic benefits in reducing caspase-3/7 activity and enhancing cell survival. Overall, Cdk2 Inhibitor II shows promise as a versatile bioactive molecule with potential applications in kinase inhibition and cellular protection..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.
靶点活性	CDK2:60 nM
别名	CDK2-IN-3, Cdk2 Inhibitor II

化学信息

分子量	395.23
分子式	C₁₄H₁₁BrN₄O₃S
CAS No.	222035-13-4
Smiles	N(NC1=CC=C(S(N)(=O)=O)C=C1)=C2C=3C(NC2=O)=CC=C(Br)C3
密度	1.85 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (126.51 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.06 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5302 mL	12.6509 mL	25.3017 mL	126.5086 mL
5 mM	0.5060 mL	2.5302 mL	5.0603 mL	25.3017 mL
10 mM	0.2530 mL	1.2651 mL	2.5302 mL	12.6509 mL
20 mM	0.1265 mL	0.6325 mL	1.2651 mL	6.3254 mL
50 mM	0.0506 mL	0.2530 mL	0.5060 mL	2.5302 mL
100 mM	0.0253 mL	0.1265 mL	0.2530 mL	1.2651 mL