Name: YAP-TEAD-IN-1
Brand: TargetMol
SKU: TP2160
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

100 mg

待询

500 mg

待询

生物活性

产品描述	YAP-TEAD-IN-1 is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM) and exhibits higher binding affinity to TEAD1 (Kd: 15 nM) compared to YAP (50-171) (Kd: 40 nM).
靶点活性	YAP-TEAD:25 nM
体外活性	In a GST pull-down assay, YAP-TEAD-IN-1 (2 μM) is against endogenous YAP binding to GST-TEAD (1209-426), the Kd of His-YAP1209-426 is determined to be 40 nM.

化学信息

分子量	2019.89
分子式	C₉₃H₁₄₄ClN₂₃O₂₁S₂
CAS No.	1659305-78-8
Smiles	[H][C@@]12CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSSC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC2=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(N)=O)NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(C)=O)C(C)C
密度	1.45 g/cm3 (Predicted)
Sequence	Ac-Val-Pro-Phe(3-Cl)-Hcy(1)-Leu-Arg-Lys-Nle-Pro-Ala-Ser-Phe-Cys(1)-Lys-Pro-Pro-Glu-NH2
Sequence Short	VPXXLRKXPASFCKPPE

储存&溶解度

存储	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

YAP-TEAD-IN-1