购物车

您的购物车当前为空

Clofoctol

Name: Clofoctol
Brand: TargetMol
SKU: T1134
Price: 118 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.87%

货号 T1134Cas号 37693-01-9

别名 叔辛酚氯, 氯福克酚

Clofoctol 是一种抗生素,，可研究革兰氏阳性菌感染。它仅对革兰氏阳性菌起作用, 可渗透入人类肺组织。

为众多的药物研发团队赋能，

让新药发现更简单！

Clofoctol

一键复制产品信息

很棒

纯度: 99.87%

货号 T1134 别名 叔辛酚氯, 氯福克酚Cas号 37693-01-9

Clofoctol 是一种抗生素,，可研究革兰氏阳性菌感染。它仅对革兰氏阳性菌起作用, 可渗透入人类肺组织。

规格	价格	库存
2 mg	¥ 118	现货
5 mg	¥ 168	现货
10 mg	¥ 229	现货
25 mg	¥ 359	现货
50 mg	¥ 513	现货
100 mg	¥ 745	现货
500 mg	¥ 2,320	现货
1 mL x 10 mM (in DMSO)	¥ 457	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.87%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Clofoctol AI Summary

Clofoctol exhibits diverse and significant bioactivities across various biological assays. It demonstrates potential for therapeutic applications by inducing the erasure of genomic imprints, inhibiting key interactions such as MLL CXXC domain - DNA interaction, Menin-MLL interaction, and the ERK signaling pathway, and enhancing SMN2 splice variant expression. Additionally, it exhibits inhibition of Tau fibril formation, Cruzain, ROR gamma transcriptional activity, Ubiquitin-specific Protease USP2a, GCN5L2, Vitamin D receptor (VDR), mammalian selenoprotein Thioredoxin Reductase 1 (TrxR1), TGF-b, cell surface uPA generation, polymerase kappa, mitochondrial permeability transition pore, ATXN expression, and several viral activities including SARS-CoV-2, vaccinia orthopoxvirus, foot-and-mouth disease virus, and Ebola virus. It acts as an allosteric/competitive inhibitor of Caspase-1, selectively targets cancer cells with p53 mutations, and modulates various cellular processes like lipid storage, cytochrome P450 3A4 activity, PINK1 expression, and GLP-1 receptor inverse agonistic effects. Specifically, in SARS-CoV-2 assays, Clofoctol shows moderate activity with inhibition rates varying based on the cellular context and assay conditions, such as a 13.88% inhibition rate in Caco-2 cells and low hit scores in HRCE cells. Additionally, it exhibits specific bioactivities such as inhibiting human HDAC6 enzyme, binding to and stabilizing TTR V3OM mutant proteins, inhibiting binding affinities towards several human receptors, and demonstrating agonistic and antagonistic activities towards various receptors. Although Clofoctol shows some level of antiviral activity against SARS-CoV-2, the inhibitory effects and potencies vary significantly, suggesting potential but requiring further optimization for therapeutic efficacy. Moreover, its diverse set of bioactivities makes it a candidate for various biomedical research avenues..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Clofoctol is a bacteriostatic antibiotic with activity against Gram-positive bacteria, used in the treatment of upper and lower respiratory tract infections.
别名	叔辛酚氯, 氯福克酚

化学信息

分子量	365.34
分子式	C₂₁H₂₆Cl₂O
CAS No.	37693-01-9
Smiles	CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1
密度	1.127 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (684.29 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.47 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7372 mL	13.6859 mL	27.3718 mL	136.8588 mL
5 mM	0.5474 mL	2.7372 mL	5.4744 mL	27.3718 mL
10 mM	0.2737 mL	1.3686 mL	2.7372 mL	13.6859 mL
20 mM	0.1369 mL	0.6843 mL	1.3686 mL	6.8429 mL
50 mM	0.0547 mL	0.2737 mL	0.5474 mL	2.7372 mL
100 mM	0.0274 mL	0.1369 mL	0.2737 mL	1.3686 mL