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Cefadroxil

Name: Cefadroxil
Brand: TargetMol
SKU: T0366
Price: 148 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 97.54%

货号 T0366Cas号 50370-12-2

别名 头孢羟氨苄, BL-S 578

Cefadroxil (BL-S 578) 是头孢菌素类广谱抗生素，有效抑制革兰氏阳性和阴性菌感染。

Cefadroxil

一键复制产品信息

很棒

纯度: 97.54%

货号 T0366 别名 头孢羟氨苄, BL-S 578Cas号 50370-12-2

Cefadroxil (BL-S 578) 是头孢菌素类广谱抗生素，有效抑制革兰氏阳性和阴性菌感染。

规格	价格	库存
25 mg	¥ 148	现货
50 mg	¥ 236	现货
100 mg	¥ 369	现货
200 mg	¥ 598	待询

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 97.54%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Cefadroxil AI Summary

Cefadroxil exhibits diverse pharmacological activities and has been extensively studied for its bioactivity. It shows significant binding affinity against various membrane transport proteins, including PEPT1 and PEPT2, with Ki values of 7,200,000 nM and 3,000 nM, respectively. It also impacts human MRP2-mediated estradiol-17-beta-glucuronide transport, showing 68.0% activity relative to control, and demonstrates moderate inhibitory activity in OAT3 transport with IC50 and Ki values of 1,780,000 nM and 8,620 nM, respectively. Pharmacokinetically, Cefadroxil has a total body clearance of 2.5 mL/min/kg and renal clearance of 2.33 mL/min/kg, indicating efficient clearance from both the body and kidneys. It has a low volume of distribution at steady state (0.23 L/kg) and moderate plasma protein binding (fraction unbound of 0.39). The compound has a half-life of 1.1 hours, a mean residence time of 1.5 hours, and demonstrates high oral bioavailability with a low human intestinal absorption rate of 1.0%. In terms of antiviral activity, Cefadroxil inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells by 31.91% at 10 µM after 48 hours. However, its efficacy against the SARS-CoV-2 3CL-Pro protease was limited, showing only 14.01% inhibition at 20 µM. Additionally, it exhibits moderate hepatotoxicity, elevating serum liver enzymes, and has a Hepatic Side Effect score of 1.0, indicating a potential for hepatic failure. Cefadroxil also demonstrated inhibitory effects on various transporters, with significant inhibition percentages seen in OATP2B1, OATP1B1, and OATP1B3 assays. However, it showed negligible inhibitory effects on the uptake of substrates in some transport assays, indicating transporter specificity. The compound's LogD7.4 value of -0.86 suggests low lipid affinity, and its intrinsic clearance rate in rat hepatocytes is less than 3.0 uL/min/million cells, indicating a low metabolic clearance rate. Overall, Cefadroxil exhibits complex bioactivity with specific affinity toward transporters and receptors, moderate clearance characteristics, potential hepatotoxicity, and some antiviral properties against SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cefadroxil (BL-S 578) is a Cephalosporin Antibacterial. The chemical classification of cefadroxil anhydrous is Cephalosporins.
别名	头孢羟氨苄, BL-S 578

化学信息

分子量	363.39
分子式	C₁₆H₁₇N₃O₅S
CAS No.	50370-12-2
Smiles	[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccc(O)cc1)C(O)=O
密度	1.59g/cm3

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 9.17 mg/mL (25.23 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7519 mL	13.7593 mL	27.5186 mL	137.5932 mL
5 mM	0.5504 mL	2.7519 mL	5.5037 mL	27.5186 mL
10 mM	0.2752 mL	1.3759 mL	2.7519 mL	13.7593 mL
20 mM	0.1376 mL	0.6880 mL	1.3759 mL	6.8797 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

PBPs Inhibitor inhibit Cefadroxil BL-S-578 BL-S578 Bacterial Antibiotic

Cefadroxil

Cefadroxil

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产品介绍

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体内实验配液计算器

剂量转换

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