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D-α-Tocopherol acetate

Name: D-α-Tocopherol acetate
Brand: TargetMol
SKU: T1016
Price: 163 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 乙酸维生素E, Vitamin E Acetate, Tocopherol acetate

货号 T1016Cas号 58-95-7 一键复制产品信息纯度: 98.84%

很棒

D-α-Tocopherol acetate (Vitamin E Acetate) 能够水解为 d-α-生育酚 (VE) 并被小肠吸收。

D-α-Tocopherol acetate

一键复制产品信息

很棒

纯度: 98.84%

货号 T1016Cas号 58-95-7

别名 乙酸维生素E, Vitamin E Acetate, Tocopherol acetate

D-α-Tocopherol acetate (Vitamin E Acetate) 能够水解为 d-α-生育酚 (VE) 并被小肠吸收。

规格	价格	库存
1 g	¥ 163	现货
2 g	¥ 219	现货
5 g	¥ 328	待询
1 mL x 10 mM (in DMSO)	¥ 179	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 98.84%

颜色: 无色透明

性状: Liquid

资源下载: COA LCMS HNMR HPLC 产品操作手册

产品介绍

D-α-Tocopherol acetate AI Summary

D-α-Tocopherol acetate has been evaluated for various bioactivities across multiple assays. It was tested for antiproliferative activity against the human breast cancer cell line MCF-7 using the MTT assay and demonstrated an IC50 value greater than 500,000 nM, indicating limited effectiveness in this context. Additionally, it inhibits GCN5L2, induces DNA re-replication in colon adenocarcinoma cells, and blocks Ebola virus entry through multiple mechanisms, showing potency in the nanomolar to micromolar range. D-α-Tocopherol acetate also protects against IL1-beta-induced cell damage in NHEK cells by inhibiting PGE2 production at concentrations of 0.1 µM, 0.5 µM, and 2 µM, with respective inhibitions of 38.0%, 40.0%, and 67.0%. It further shows a protective effect against t-BHP-induced cell damage with 77.4% inhibition and against H2O2-induced cell damage with 25.0% inhibition at 2 µM after 24 hours. In mouse N18TG2 cells, the compound undergoes complete degradation, leading to 100.0% alpha-TOH formation after 24 hours. Moreover, it weakly inhibits the bovine mitochondrial electron transport protein complex 2 succinate: DCPIP oxidoreductase activity with an IC50 value higher than 1,000,000 nM. D-α-Tocopherol acetate also acts as a SARS-CoV-2 3CL-Pro protease inhibitor, showing 30.78% inhibition at 20 µM. Despite this, it exhibits minimal antiviral activity against SARS-CoV-2 with a 0.17% inhibition rate in VERO-6 cells at 10 µM after 48 hours. While demonstrating moderate inhibitory activity against PDE3A and PDE4A with AC50 values of 932.7 nM and 9,379.5 nM, respectively, its binding affinity and bioactivity concerning various receptors and enzymes generally remain low, with AC50 values exceeding 30,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	D-alpha-Tocopherol acetate (Vitamin E Acetate) is hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.
别名	乙酸维生素E, Vitamin E Acetate, Tocopherol acetate

化学信息

分子量	472.74
分子式	C₃₁H₅₂O₃
CAS No.	58-95-7
Smiles	CC1=C2C(=C(C)C(OC(C)=O)=C1C)CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2
密度	0.953 g/mL at 25°C(lit.)

储存&溶解度

存储

溶解度信息

DMSO: 250 mg/mL (528.83 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1153 mL	10.5766 mL	21.1533 mL	105.7664 mL
5 mM	0.4231 mL	2.1153 mL	4.2307 mL	21.1533 mL
10 mM	0.2115 mL	1.0577 mL	2.1153 mL	10.5766 mL
20 mM	0.1058 mL	0.5288 mL	1.0577 mL	5.2883 mL
50 mM	0.0423 mL	0.2115 mL	0.4231 mL	2.1153 mL
100 mM	0.0212 mL	0.1058 mL	0.2115 mL	1.0577 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

VE Tocopherol Acetate Inhibitor inhibit EndogenousMetabolite Endogenous Metabolite D-α-Tocopherol Acetate DαTocopherol acetate D-Vitamin E D-a-Tocopherol Acetate D-alpha-Tocopherol Acetate D α Tocopherol acetate

D-α-Tocopherol acetate

D-α-Tocopherol acetate