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D-Sorbitol

Name: D-Sorbitol
Brand: TargetMol
SKU: T0332
Price: 136 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.67%

货号 T0332Cas号 50-70-4

别名 山梨醇, Sorbitol, Glucitol, D-Glucitol

D-Sorbitol (Sorbitol) 是一种六碳糖醇，能够用作糖的替代品。D-Sorbitol 能够用作稳定的赋形剂和/或等渗剂，保湿剂，增稠剂，甜味剂和膳食补充剂。

D-Sorbitol

一键复制产品信息

很棒

纯度: 99.67%

货号 T0332 别名 山梨醇, Sorbitol, Glucitol, D-GlucitolCas号 50-70-4

D-Sorbitol (Sorbitol) 是一种六碳糖醇，能够用作糖的替代品。D-Sorbitol 能够用作稳定的赋形剂和/或等渗剂，保湿剂，增稠剂，甜味剂和膳食补充剂。

规格	价格	库存
25 mg	¥ 136	现货
50 mg	¥ 200	现货
100 mg	¥ 259	现货
500 mg	¥ 593	现货
1 g	¥ 866	现货
1 mL x 10 mM (in DMSO)	¥ 215	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.67%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

D-Sorbitol AI Summary

D-Sorbitol demonstrates a range of bioactivities across various biological targets. It inhibits Human acrosin by 38.0% when tested with polyols and shows significant inhibition of several cellular functions, including HP1-beta chromodomain interactions with methylated histone tails, human flap endonuclease 1 (FEN1), and human apurinic/apyrimidinic endonuclease 1 (APE1). Additionally, it induces DNA re-replication in normal breast cells. Against SARS-CoV-2, D-Sorbitol exhibits modest antiviral activity, inhibiting cytotoxic effects on Caco-2 cells by 29.88% at a concentration of 10 µM after 48 hours, and showing 13.85% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM based on a FRET assay. However, it has low potency in VERO-6 cells, with only 0.08% inhibition of cytotoxicity at 10 µM after 48 hours and an IC50 value greater than 20,000.0 nM. In enzymatic assays, D-Sorbitol inhibits human HDAC6 by 33.03% using a commercial peptide substrate and by 4.23% with a custom peptide substrate. Despite its multiple binding affinities towards human receptors and enzymes, it is not significantly effective as the AC50 values exceeded 30,000.0 nM, indicating low potency in these assays. Importantly, D-Sorbitol does not induce drug-induced liver injury, with a DILI severity class index of 0.0, suggesting it does not exhibit liver toxicity in the assessed models..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

D-Sorbitol (Sorbitol) is a polyhydric alcohol with about half the sweetness of sucrose. D-Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.

别名

山梨醇, Sorbitol, Glucitol, D-Glucitol

化学信息

分子量	182.17
分子式	C₆H₁₄O₆
CAS No.	50-70-4
Smiles	[C@H]([C@@H]([C@@H](CO)O)O)([C@H](CO)O)O
密度	1.28 g/cm3 at 25℃

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 100 mg/mL (548.94 mM), Sonication is recommended.

DMSO: 255 mg/mL (1399.79 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (27.45 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4894 mL	27.4469 mL	54.8938 mL	274.4689 mL
5 mM	1.0979 mL	5.4894 mL	10.9788 mL	54.8938 mL
10 mM	0.5489 mL	2.7447 mL	5.4894 mL	27.4469 mL
20 mM	0.2745 mL	1.3723 mL	2.7447 mL	13.7234 mL
50 mM	0.1098 mL	0.5489 mL	1.0979 mL	5.4894 mL
100 mM	0.0549 mL	0.2745 mL	0.5489 mL	2.7447 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Xylose isomerase thickener sweetener sugar Six-carbon Malate synthase G isotonicity Inhibitor inhibit humectant EndogenousMetabolite Endogenous Metabolite D-Sorbitol DSorbitol D Sorbitol alcohol

D-Sorbitol

D-Sorbitol

D-Sorbitol 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词