规格

价格

库存

数量

1 mg

¥ 329

现货

5 mg

¥ 778

现货

10 mg

¥ 1,320

现货

25 mg

¥ 2,890

现货

50 mg

¥ 4,370

现货

100 mg

¥ 6,230

现货

500 mg

¥ 12,700

现货

1 mL x 10 mM (in DMSO)

¥ 853

现货

生物活性

产品描述	RO5263397 is a TAAR1 specific agonist with oral activity that has been used in antidepressant studies. It has also been found to act as an inhibitor of the enzyme cyclooxygenase-2 (COX-2), which is involved in the synthesis of prostaglandins.
体内活性	Dosing at the mid-light phase (ZT6)(RO5263397) increased wake time at 0.3 and 1 mg/kg. RO5263397 ecreases NREM time in WT mice. RO5263397 (0.3 and 1.0 mg/kg; p.o.; in OE mice) powerfully increases W time in OE mice for 5-6 h. NREM sleep is suppressed for 4-6 h and REM sleep is almost completely suppressed for 6 h after all doses of RO5263397[3].

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 234 mg/mL (1204.88 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (25.75 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO