规格

价格

库存

数量

1 mg

¥ 793

现货

5 mg

¥ 1,730

现货

10 mg

¥ 2,570

现货

25 mg

¥ 3,970

现货

50 mg

¥ 5,860

现货

100 mg

¥ 7,880

现货

1 mL x 10 mM (in DMSO)

¥ 2,270

现货

生物活性

产品描述	MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).
靶点活性	MYC:3.2 μM(Kd)
体外活性	MYCi361 is a small-molecule MYC inhibitors that inhibits the viability of MYC-dependent cancer cells including prostate cancer (MycCaP, LNCaP, and PC3), leukemia (MV4-11), lymphoma (HL-60 and P493-6), and neuroblastoma (SK-N-B2) with low-micromolar IC50 values[1].
体内活性	MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy.
动物实验	FVB or NSG male mice of 6-8 weeks of age and 25 g bearing established MycCaP tumors.MYCi361 treatment i.p. initially at 50 mg/kg twice daily for 2 days, then 70 mg/kg/day for 9 days
别名	NUCC-0196361

化学信息

分子量	594.86
分子式	C₂₆H₁₆ClF₉N₂O₂
CAS No.	2289690-31-7
Smiles	Cn1nc(cc1-c1ccc(OCc2ccc(Cl)cc2)c(c1O)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(F)(F)F
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (168.11 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (5.55 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO