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经典已知活性库

经典已知活性库

产品编号 L4000 Bioactive Compound Library
  库化合物信息   Excel SDF

经典已知活性库是14590 个具有生物活性,能引起细胞、组织甚至个体生物学反应的化合物的集合。包括了正在进行临床前研究的药物分子,临床期的药物分子和已经上市的药物。靶点明确,信息全面,非常适合完成药物功能重定位、小分子诱导细胞分化以及机制研究中蛋白靶点确认等科研工作。

由于活性明确,靶点已知,很多科学家会从已知活性库中选择可以用于细胞诱导分化的小分子;通过单一或几个小分子的联合作用,筛选出能将各种体细胞诱导成为诱导多能干细胞,神经前体细胞,心肌细胞等的分子;甚至还有使用小分子组合在体内完成诱导分化的成功尝试。

包含L4000已知活性库在内,TargetMol 可以提供多达4万种生物活性已知的小分子化合物,可以满足您在各个阶段的科研工作需要,欢迎随时和我们联系。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
TargetMol Compound Library
规格
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
如果上述化合物库无法满足您的需求,您可发送邮件至tech@targetmol.com咨询我们的技术专员,为您量身定制专属化合物库!
咨询化合物库
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产品描述

  • 14590个已知活性化合物的集合,可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认;
  • 所有化合物都有相应的靶点信息的描述,靶点信息已知;
  • 是老药新用、细胞诱导靶点筛选的有效工具;
  • 涵盖多个疾病研究领域,如癌症、代谢、免疫和心血管系统等;
  • 详细的说明书,化合物结构、靶点信息、活性描述等;
  • 结构多样,药效显著,可渗透细胞;
  • NMR、HPLC/ LCMS多重检测,保证产品结构准确,纯度高,保障实验顺利进行。

化合物库定制

TargetMol的化合物可以高度定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L4000)
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TargetMol Library Books客户使用化合物库发表的文献

1. ACS nano. 2023. 2. Advanced Science. 2022: 2203388.. 3. Advanced Science. 2020, 7(16): 2000925. 4. Angewandte Chemie. 2021. 5. Signal transduction and targeted therapy. 2021, 6(1): 1-4. 6. Autophagy. 2023: 1-20. 7. Angewandte Chemie International Edition. 2020, 59(24): 9601-9609. 8. The EMBO Journal. 2021, 40(16): e107403. 9. Journal of Cell Biology. 2022, 221(5): e202112024.
10. Cell Reports. 2022, 39(2): 110622. 12. Journal of Translational Medicine. 2023, 21(1): 1-20.. 13. Acta Pharmaceutica Sinica B. 2021 Jun;11(6):1555-1567. 14. Frontiers in Molecular Biosciences. 2022, 9. 15. Marine Drugs. 2023, 21(4): 218. 16. Pharmaceuticals. 2022, 15(5): 556. 17. Frontiers in chemistry. 2022, 10. 18. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022, 37(1): 109-117.. 19. Methods. 2022, 205: 247-262. 20. ACS Infectious Diseases. 2021 Aug 13;7(8):2337-2351. 21. European Journal of Pharmaceutical Sciences. 2023: 106672.. 22. Cancer Science. 2021, 112(11): 4722. 23. Cognitive computation. 2021 Feb 2;1-13. 24. Neoplasia. 2020, 22(4): 179-191. 25. Investigational New Drugs. 2019 May 14: 1-10. 26. Acta Biochimica et Biophysica Sinica. 2021. 27. Interdisciplinary Sciences, Computational Life Sciences. 2020, 12: 368-376. 28. SSRN. 2023. 29. Journal of Southern Medical University. 2022, 42(4): 554-560. 30. bioRxiv. 2022. 31. Journal of Southern Medical University. 2021, 41(12): 1835-1842. 32. bioRxiv. 2021 Feb 15;2021.02.13.431008. 33. Cell Stem Cell. 2022 Apr 29(4) 545–558. 34. Science Bulletin. 2022. 35. Science Translational Medicine. 2022, 14(656): eabn3231. 36. Science Advances. 2023, 9(9): eade3760. 37. Nature. 2020, 582: 289-293. 38. Nature Biotechnology. 2021, 39(11): 1444-1452. 39. Nature Communications. 2022, 13(1): 1-15.. 40. Nature Communications. 2023, 14(1): 1020.. 41. Nature Communications. 2023, 14(1): 2756.. 42. Blood. 2021, 137(11): 1478-1490. 43. Nucleic Acids Research. 2021. 44. Nature Communications. 2023, 14(1): 7574. 45. Acta Pharmaceutica Sinica B. 2022. 46. Protein & Cell. 2021, 12(11): 877-888. 47. Bone Research. 2023, 11(1): 54. 48. Pharmacology & Therapeutics. (2021): 107930. 49. Nature Communications. 2021, 12(1): 1-12. 50. Duo L, Chen Y, Liu Q, et al.Discovery of Novel SOS1 Inhibitors Using Machine Learning.RSC Medicinal Chemistry.2024 51. Wilson D M, Driedger D J, Liu D Y, et al.Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides.Nature Communications.2024, 15(1): 2534. 52. Lv S, Pan Q, Lu W, et al.Tenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells.Scientific Reports.2024, 14(1): 7654.
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化合物库组成

Apoptosis (1140)
Antibacterial (885)
Autophagy (818)
Endogenous Metabolite (801)
Antibiotic (535)
5-HT Receptor (361)
AChR (305)
Antifungal (287)
Parasite (281)
COX (271)
Adrenergic Receptor (250)
DNA/RNA Synthesis (244)
NF-κB (240)
Dopamine Receptor (224)
CDK (216)
HIV Protease (211)
Calcium Channel (200)
PI3K (200)
Potassium Channel (197)
EGFR (181)
Reactive Oxygen Species (174)
P450 (173)
Histamine Receptor (167)
PDE (165)
VEGFR (162)
Epigenetic Reader Domain (158)
Dehydrogenase (155)
Sodium Channel (147)
Influenza Virus (143)
GABA Receptor (139)
Antioxidant (137)
PPAR (132)
GluR (129)
Histone Methyltransferase (124)
Microtubule Associated (124)
HDAC (122)
TRP/TRPV Channel (121)
JAK (111)
TNF (110)
mTOR (106)
Wnt/beta-catenin (106)
GPR (103)
Topoisomerase (103)
Akt (102)
p38 MAPK (101)
FLT (100)
ERK (99)
Prostaglandin Receptor (98)
Ferroptosis (98)
Estrogen/progestogen Receptor (97)
Src (97)
Phosphatase (96)
PDGFR (94)
Adenosine Receptor (92)
iGluR (92)
AChE (92)
STAT (89)
SARS-CoV (89)
Estrogen Receptor/ERR (86)
HCV Protease (85)
PARP (84)
PKC (84)
FGFR (82)
AMPK (81)
GSK-3 (81)
NMDAR (81)
Opioid Receptor (79)
RAAS (79)
IL Receptor (79)
Nucleoside Antimetabolite/Analog (78)
Raf (77)
Caspase (77)
Virus Protease (76)
NO Synthase (75)
MMP (73)
c-Kit (73)
BCL (73)
c-Met/HGFR (69)
Ras (69)
MAO (68)
Proteasome (67)
Androgen Receptor (67)
Antiviral (67)
Glucocorticoid Receptor (67)
Lipoxygenase (67)
TLR (66)
HSP (66)
Phospholipase (66)
ATPase (64)
Sirtuin (64)
Bcr-Abl (64)
HBV (63)
Beta Amyloid (62)
HSV (62)
Mitochondrial Metabolism (62)
Anti-infection (61)
Cannabinoid Receptor (61)
ROS (59)
TGF-beta/Smad (58)
Aurora Kinase (56)
ALK (56)
Tyrosinase (54)
Mitophagy (54)
MAPK (53)
Drug Metabolite (53)
E1/E2/E3 Enzyme (51)
HIF/HIF Prolyl-Hydroxylase (51)
BTK (51)
JNK (51)
DUB (50)
HER (48)
MEK (48)
Antifection (47)
Casein Kinase (47)
Nrf2 (47)
Tyrosine Kinases (47)
NOS (46)
CCR (46)
Carbonic Anhydrase (46)
Monoamine Oxidase (46)
ROCK (45)
Transferase (45)
Interleukin (45)
P-gp (43)
PKA (43)
IκB/IKK (43)
p53 (43)
Reverse Transcriptase (43)
HIF (42)
Histone Demethylase (42)
Retinoid Receptor (42)
IGF-1R (41)
Serine/threonin kinase (41)
Gamma-secretase (41)
Serotonin Transporter (39)
DNA-PK (39)
P2X Receptor (39)
Integrin (39)
S1P Receptor (38)
CXCR (37)
c-RET (36)
Cysteine Protease (35)
Norepinephrine (35)
TAM Receptor (35)
Immunology/Inflammation related (34)
LPL Receptor (34)
CaMK (33)
ribosome (33)
Serine Protease (33)
Reductase (33)
Hedgehog/Smoothened (33)
S6 Kinase (32)
Proton pump (32)
Trk receptor (32)
Histone Acetyltransferase (32)
FAK (31)
RIP kinase (30)
Chloride channel (30)
Glucosidase (30)
FAAH (30)
Sigma receptor (30)
Ligand for E3 Ligase (29)
Progesterone Receptor (29)
PLK (29)
c-Fms (28)
Fatty Acid Synthase (27)
NADPH (27)
transporter (27)
Thrombin (26)
Aryl Hydrocarbon Receptor (26)
CFTR (26)
NOD (26)
Glucokinase (26)
Mdm2 (26)
DPP-4 (25)
ATM/ATR (25)
Syk (25)
Chk (24)
Kinesin (24)
Acyltransferase (24)
Protease-activated Receptor (24)
DNA Alkylator/Crosslinker (23)
DNA Methyltransferase (23)
PERK (23)
Pim (23)
Rho (23)
Amino Acids and Derivatives (23)
Smo (22)
PDK (22)
HMG-CoA Reductase (22)
Endothelin Receptor (22)
Indoleamine 2,3-Dioxygenase (IDO) (22)
ROR (22)
DNA (22)
FXR (22)
AhR (21)
Thyroid hormone receptor(THR) (21)
P2Y Receptor (21)
Lipase (21)
SGLT (21)
Glutathione Peroxidase (21)
Neurokinin receptor (21)
IRAK (20)
MRP (20)
Epoxide Hydrolase (20)
Glucagon Receptor (20)
Factor Xa (19)
DYRK (19)
LTR (19)
LRRK2 (19)
Hydroxylase (19)
Guanylate cyclase (19)
Xanthine Oxidase (19)
STING (18)
Complement System (18)
cAMP (18)
PAK (18)
DHFR (17)
OX Receptor (17)
PD-1/PD-L1 (17)
LPA Receptor (17)
Antifolate (17)
Leukotriene Receptor (16)
Neuropeptide Y Receptor (16)
IRE1 (16)
Myosin (16)
NOD-like Receptor (NLR) (16)
DNA Alkylation (15)
Aromatase (15)
DNA gyrase (15)
Platelet aggregation (15)
BACE (15)
YAP (15)
Liver X Receptor (15)
c-Myc (15)
IAP (14)
Lipid (14)
Ephrin Receptor (14)
GTPase (14)
PGE Synthase (14)
CSF-1R (14)
PI4K (14)
Vasopressin Receptor (13)
ABC (13)
Aminopeptidase (13)
ROS Kinase (13)
cholecystokinin (13)
RSV (13)
Telomerase (12)
Beta-Secretase (12)
GPCR19 (12)
CETP (12)
Stearoyl-CoA Desaturase (SCD) (11)
Bradykinin Receptor (11)
Discoidin Domain Receptor (DDR) (11)
CaSR (11)
Isocitrate Dehydrogenase (IDH) (11)
Melanocortin Receptor (11)
NADPH-oxidase (11)
GHSR (11)
Phosphorylase (11)
PAI-1 (11)
Free radical scavengers (11)
Monocarboxylate transporter (11)
Monoamine Transporter (11)
Acetyl-CoA Carboxylase (11)
Neurotensin Receptor (11)
LDL (10)
PKM (10)
Imidazoline Receptor (10)
IDO (10)
Melatonin Receptor (10)
NAMPT (10)
IFNAR (10)
ATP Citrate Lyase (9)
GRK (9)
MLK (9)
BCRP (9)
MT Receptor (9)
SGK (9)
PROTACs (9)
UGT (9)
CAT (9)
Adenylyl cyclase (8)
ASK (8)
Dynamin (8)
Wee1 (8)
Porcupine (8)
Glutaminase (8)
PTEN (8)
GST (8)
Neprilysin (8)
Ligands for Target Protein for PROTAC (8)
Arrestin (8)
Tie-2 (7)
MNK (7)
SIK (7)
Arginase (7)
GlyT (7)
Na+/Ca2+ Exchanger (7)
OCT (7)
PAD (7)
p97 (7)
Annexin A (7)
Adenosine deaminase (6)
Somatostatin (6)
TOPK (6)
RAR/RXR  (6)
FLAP (6)
GPX (6)
APC (6)
Aquaporin (6)
AAK1 (AP2 associated kinase 1) (6)
MELK (6)
MyD88 (6)
Molecular Glues (6)
MAGL (6)
Carboxypeptidase (6)
PAFR (6)
OAT (6)
CRISPR/Cas9 (6)
CRM1 (5)
cell cycle arrest (5)
LIM Kinase (5)
MTH1 (5)
Hippo pathway (5)
Angiotensin-converting Enzyme (ACE) (5)
GNRH Receptor (5)
PYK2 (5)
DprE1 (5)
Amylase (5)
Gap Junction Protein (5)
VDAC (5)
TSH Receptor (5)
Methionine Adenosyltransferase (MAT) (5)
Oxytocin Receptor (5)
ACK (5)
cGAS (5)
Decarboxylase (5)
CGRP Receptor (5)
OXPHOS (5)
CRFR (5)
Bombesin Receptor (5)
BMI-1 (5)
Survivin (4)
Adiponectin receptor (4)
MALT (4)
Thrombopoietin Receptor (4)
advanced glycation end products (4)
NEDD8 (4)
Galectin (4)
Pyroptosis (4)
Cell wall (4)
Melanin-concentrating Hormone Receptor (MCHR) (4)
KSP (4)
CD73 (4)
DAPK (4)
PROTAC Linker (4)
NPC1L1 (4)
Glutathione reductase (3)
HCN Channel (3)
Hexokinase (3)
CPT (3)
KLF (3)
AIM2 (3)
Necroptosis (3)
CD38 (3)
Hck (3)
RANKL/RANK (3)
Apelin receptor (3)
Transaminase (3)
GluCls (3)
Na-K-Cl cotransporter (3)
Haspin Kinase (3)
Integrase (2)
Fas/FasL (2)
VDA (2)
lysosomal autophagy (2)
EBI2/GPR183 (2)
ATTECs (2)
Taste receptor (2)
hCE (2)
GSNOR (2)
Prolyl Endopeptidase (PREP) (2)
Protease (2)
NUDIX hydrolase (2)
gp120/CD4 (2)
PGC-1α (2)
FOXO1 (1)
LHRH (1)
Piezo Channel (1)
PACAP (1)
Procollagen C Proteinase (1)
Thioredoxin (1)
stilbene oxidase (1)
Stemness kinase (1)
Fer/FerT kinase (1)
NMU2R (1)
aconitase (1)
Motilin Receptor (1)
Hydrogenase (1)
Neuropeptide W (1)
CYP19A1 (1)
FKBP (1)
RXFP receptor (1)
N-Acetylglucosaminyltransferase (1)
Anion Exchanger (1)
HuR (1)
FABP (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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