Sarizotan 2HCl is an hERG channel inhibitor and 5-hydroxytryptamine 5-HT1A receptor agonist with potential antidepressant effects for the study of Parkinsonian movement disorders.

5-HT 1A Receptor:0.1 nM, 5-HT 2A Receptor:587 nM, 5-HT7 receptor (human):10 nM, 5-HT6 receptor (human):3300 nM, D3 receptor (human):6.8 nM, 5-HT5A receptor:313 nM, 5-HT2B receptor:108 nM

与仅接受左多巴治疗的大鼠相比，Sarizotan 2HCl（10 ng和1 μg在0.3 μL溶液中）在更高剂量（10 ng和1 μg）下的亚丙酸（Subthalamic）给药明显降低了体重为220-240克的雄性斯普拉格-道利大鼠的旋转反应评分。