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Mycophenolic acid sodium

产品编号 T61099 CAS 37415-62-6

Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), exhibiting an EC50 of 0.24 μM. It has broad antiviral activity against RNA viruses, including influenza. Additionally, mycophenolic acid sodium possesses immunosuppressive properties and exerts antiangiogenic and antitumor effects [1][2].

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Mycophenolic acid sodium Chemical Structure

Mycophenolic acid sodium, CAS 37415-62-6

规格	价格/CNY	货期
25 mg	￥ 14,900	8-10周
50 mg	￥ 19,420	8-10周
100 mg	￥ 24,625	8-10周

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Mycophenolic acid sodium 的其他形式现货产品:

Mycophenolic acid

其他形式的 Mycophenolic acid sodium:

Mycophenolic acid
现货
Mycophenolic acid-d3
询价

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生物活性

化学信息

存储 & 溶解度

产品描述	Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), exhibiting an EC50 of 0.24 μM. It has broad antiviral activity against RNA viruses, including influenza. Additionally, mycophenolic acid sodium possesses immunosuppressive properties and exerts antiangiogenic and antitumor effects [1][2].
体外活性	Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus [1]. IMPDH is the rate-limiting enzyme in the de novo synthesis of guanosine nucleotides [2]. Mycophenolic acid (0.01-1 μM; 72 hours) sodium exhibits preferential antiproliferative activity against the endothelial cells and fibroblasts. Endothelial cells are most sensitive cells to Mycophenolic acid treatment with an IC 50 <500 nM for antimitotic effects [2]. Fibroblasts are also prone to Mycophenolic acid-induced cell cycle inhibition but exhibit a higher IC 50 (<1 μM) compared with endothelial cells. The two human tumor cell lines A549 non-small cell lung cancer cells and PC3 prostate cancer cells show intermediate sensitivity with an IC 50 >1 μM. U87 glioblastoma cells are resistant against Mycophenolic acid sodium treatment up to 1 μM [2]. Mycophenolic acid (0.05-2 μM; 18 hours) sodium exhibits a dose-dependent down-regulation of HDAC2 and MYC, whereas up-regulates NDRG1 [2]. Cell Proliferation Assay [2] Cell Line: Primary isolated human dermal microvascular endothelial cells (HDMVEC), fibroblasts, U87 glioblastoma cells, PC3 prostate cancer cells, A549 non-small cell lung cancer cells. Concentration: 0.01, 0.1, 1 μM Incubation Time: 72 hours Result: Exhibited preferential antiproliferative activity against HDMVEC and fibroblasts. Whereas U87 glioblastoma cells were resistant to treatment, A549 non-small cell lung cancer and PC3 prostate cancer cells showed intermediate sensitivity. Western Blot Analysis [2] Cell Line: HDMVEC Concentration: 0, 0.05, 0.1, 0.5, 1, and 2 μM Incubation Time: 18 hours Result: Showed a dose-dependent regulation of HDAC2, MYC, and NDRG1.
体内活性	Mycophenolic acid (120 mg/kg; oral gavage; b.i.d.) sodium exerts its antitumor effects via modulation of the tumor microenvironment, U87 tumor growth is markedly inhibited in vivo in BALB/c nude mice [2]. Animal Model: Athymic 8-week-old, 20 g BALB/c nu/nu mice bearing Mycophenolic acid-resistant human U87 tumor model [2] Dosage: 120 mg/kg MMF (the morpholinoethyl ester prodrug of Mycophenolic acid) Administration: Oral gavage; b.i.d. Result: MMF (the morpholinoethyl ester prodrug of Mycophenolic acid) significantly inhibited tumor growth (～70% after day 14 after tumor implantation) in MMF-treated versus control mice. Microvessel density (CD31 staining) and pericyte coverage determined by α-smooth muscle actin staining were markedly reduced in MMF-treated versus control tumors (44% and 78%, respectively).

分子量	342.323
分子式	C17H19NaO6
CAS No.	37415-62-6

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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