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Anti-Serpin B6 Antibody (6G141) 是一种 Rabbit 抗体,靶向 Serpin B6。Anti-Serpin B6 Antibody (6G141) 可用于 ELISA。
Anti-Serpin B6 Antibody (6G141) 是一种 Rabbit 抗体,靶向 Serpin B6。Anti-Serpin B6 Antibody (6G141) 可用于 ELISA。
产品描述 | Anti-Serpin B6 Antibody (6G141) is a Rabbit antibody targeting Serpin B6. Anti-Serpin B6 Antibody (6G141) can be used in ELISA. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 6G141 |
交叉反应 | Human |
应用 | ELISA |
推荐剂量 | ELISA: 1:5000-1:10000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinB6 (rh SerpinB6; TMPY-02242; AAB30320.1; Asp 2-Pro 376). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-6 is an inhibitor of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. SerpinB6 / PI-6 is expressed in keratinocytes (at protein level). It is also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. SerpinB6 / PI-6 is expressed in the inner ear hair cells. It’s expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. SerpinB6 / PI-6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Defects in SerpinB6 are the cause of deafness autosomal recessive type 91 which is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal. |
偶联 | Unconjugated |
免疫原 | Recombinant Human SerpinB6 protein (TMPY-02242) |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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