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Otilonium bromide
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很棒纯度: 99.78%
货号 T1474Cas号 26095-59-0
别名 奥替溴铵, SP63, Octylonium bromide
Otilonium bromide (SP63) 是一种抗毒蕈碱药，用作解痉剂。
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Otilonium bromide
一键复制产品信息 很棒纯度: 99.78%
货号 T1474 别名 奥替溴铵, SP63, Octylonium bromideCas号 26095-59-0
Otilonium bromide (SP63) 是一种抗毒蕈碱药，用作解痉剂。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 mg | ¥ 151 | 现货 | |
| 10 mg | ¥ 228 | 现货 | |
| 25 mg | ¥ 328 | 现货 | |
| 50 mg | ¥ 448 | 现货 | |
| 100 mg | ¥ 648 | 现货 | |
| 500 mg | ¥ 1,630 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 236 | 现货 |
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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
产品介绍
Otilonium bromide AI Summary
Otilonium bromide exhibits multiple bioactivities across different biological targets and assays. It demonstrates inhibition of human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 29855.4 nM in cells without CPT and 33498.3 nM with CPT. Additionally, it shows a potency of 14125.4 nM in a gametocytocidal assay and blocks Ebola Virus entry with AC50 values between 10.0 μM and 25118.9 nM in various assays. The compound has an IC50 of 8465.81 nM in a VEGF-stimulated co-culture viability assay and 10000.0 nM in a tube area decrease assay.
Furthermore, Otilonium bromide displays antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 3.5% at 10 μM after 48 hours and shows 0.1403% inhibition of SARS-CoV-2 3CL-Pro protease at 20 μM. It also inhibits cytotoxicity in VERO-6 cells exposed to SARS-CoV-2 under similar conditions.
Moreover, Otilonium bromide exhibits inhibition of the human KCNH2 channel with an AC50 of 660.0 nM and the human ADRB1 with an AC50 of 10999.9 nM. It binds to various receptors, including SLC6A3, HTR2C, OPRK1, and SLC6A2, and acts as an agonist at receptors like CHRM2, HTR1A, and ADRA1A with AC50 values between 10999.9 nM and 16000.0 nM. It acts as an antagonist at receptors such as PGR, NR1I2, HTR2A, and HTR2B with varying AC50 values.
Overall, Otilonium bromide shows diverse bioactivities, impacting viral entry and replication, receptor interactions across different pathways, and inhibiting important enzymes and proteins..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent. |
| 靶点活性 | mAChR:880 nM |
| 体内活性 | Otilonium bromide由于其溶解和吸收性质,主要在局部发挥作用。Otilonium bromide在肠平滑肌细胞内外调整Ca2 +通量,对于胃肠道末端具有选择性的解痉挛活性。 |
| 别名 | 奥替溴铵, SP63, Octylonium bromide |
| 分子量 | 563.57 |
| 分子式 | C29H43BrN2O4 |
| CAS No. | 26095-59-0 |
| Smiles | C(CCCCCCC)Oc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1.[Br-] |
| 密度 | no data available |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 55 mg/mL (97.59 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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