Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Acifluorfen 是一种除草剂。Acifluorfen 是一种原卟啉原氧化酶抑制剂,可促进原卟啉 IX 的积累,并诱导啮齿动物肝脏发生肿瘤。它会引起敏感植物物种中的色素和脂质强烈的光氧化破坏。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 294 | 现货 | ||
50 mg | ¥ 417 | 现货 | ||
100 mg | ¥ 629 | 现货 | ||
500 mg | ¥ 1,562 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 387 | 现货 |
产品描述 | Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX) and induces tumors in rodent livers. It causes significant photooxidative damage to pigments and lipids in sensitive plant species. |
体外活性 | In order to assess the relationship between herbicide activity and endogenous antioxidants, the effect of Acifluorfen on glutathione and ascorbate levels in cucumber (Cucumis sativus L.) cotyledon discs is investigated. Acifluorfen decreases the levels of glutathione and ascorbate over 50% in discs exposed to less than 1.5 hours of white light (450 microeinsteins per square meter per second). Acifluorfen also causes the rapid depletion of ascorbate in far-red light grown plants which are photosynthetically incompetent [2]. |
体内活性 | Dietary treatment with 2500 ppm Acifluorfen for up to 13 weeks increases Cyp2b10 expression in the livers of wild-type mice, but not in CAR-knockout (CARKO) mice. Microscopically, Acifluorfen treatment-induces cytotoxic changes, including hepatocellular necrosis and inflammation, and causes regenerative changes accompanied by prolonged increases in the numbers of proliferating cell nuclear antigen-positive hepatocytes in WT mice [1]. These results indicated that prolonged cytotoxicity in the liver was a key factor for ACI-induced hepatocarcinogenesis, and that CAR played an important role in ACI-induced liver injury and tumor development in mice. |
分子量 | 361.66 |
分子式 | C14H7ClF3NO5 |
CAS No. | 50594-66-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (165.9 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.765 mL | 13.8251 mL | 27.6503 mL | 69.1257 mL |
5 mM | 0.553 mL | 2.765 mL | 5.5301 mL | 13.8251 mL | |
10 mM | 0.2765 mL | 1.3825 mL | 2.765 mL | 6.9126 mL | |
20 mM | 0.1383 mL | 0.6913 mL | 1.3825 mL | 3.4563 mL | |
50 mM | 0.0553 mL | 0.2765 mL | 0.553 mL | 1.3825 mL | |
100 mM | 0.0277 mL | 0.1383 mL | 0.2765 mL | 0.6913 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Acifluorfen 50594-66-6 Others glutathione inhibit hepatocytes Inhibitor herbicide ascorbate tumors cytotoxic inhibitor