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Thiamphenicol

Name: Thiamphenicol
Brand: TargetMol
SKU: T1550
Price: 148 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.8%

货号 T1550Cas号 15318-45-3

别名 甲砜霉素, Thiophenicol, Dextrosulphenidol

Thiamphenicol (Dextrosulphenidol) 是 Chloramphenicol 的甲基磺酰基衍生物，是一种广谱抗菌类抗生素。它与 50S 核糖体亚基结合，抑制蛋白质合成并具有抑菌作用，特别针对革兰氏阴性，革兰氏阳性需氧和厌氧菌。

Thiamphenicol

一键复制产品信息

很棒

纯度: 99.8%

货号 T1550 别名 甲砜霉素, Thiophenicol, DextrosulphenidolCas号 15318-45-3

规格	价格	库存
50 mg	¥ 178	现货
100 mg	¥ 247	现货
500 mg	¥ 413	现货
1 g	¥ 579	现货
1 mL x 10 mM (in DMSO)	¥ 148	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.8%

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COA LCMS HNMR 产品操作手册

产品介绍

Thiamphenicol AI Summary

Thiamphenicol exhibits a range of bioactivities and physicochemical properties. It has been tested for inhibition of the puromycin reaction, demonstrating an inhibition constant (Ki) of 400.0 nM. The compound has a moderate hydrophobic profile with a low partition coefficient (logP) and a logD7.4 of -0.27, indicating a preference for the aqueous layer over the organic layer at physiological pH. It shows cytotoxic activity against various strains of Streptococcus and inhibition of Streptokinase Promoter Activity, with EC50 values ranging from 740.0 nM to 4552.0 nM. Additionally, it inhibits the PhoP region in Salmonella Typhimurium with IC50 values between 18030.0 nM and 86160.0 nM. Thiamphenicol demonstrates inhibitory effects on several targets, including human tyrosyl-DNA phosphodiesterase 1, malaria parasite plastid, HP1-beta Chromodomain interactions, and Plasmodium falciparum proliferation, with potency values ranging from 2269.5 nM to 89125.1 nM. It has anti-SARS-CoV-2 activity, inhibiting the SARS-CoV-2 3CL-Pro protease by 16.32% at 20µM and reducing cytotoxicity in Caco-2 and VERO-6 cells at various concentrations. The compound exhibits moderate hepatotoxicity, with evidence of acute liver toxicity, and affects several liver function parameters (ALT, AST, ALP, and bilirubin) as well as kidney function markers and blood chemistry parameters. It shows inhibitory activity towards human HDAC6 enzyme, with an inhibition rate of 10.91% using a commercial peptide substrate. In transporter assays, Thiamphenicol inhibits multiple transport proteins such as BSEP, MRP2, MRP3, and MRP4 with relatively low potency (IC50 values >133000.0 nM). It also affects sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected cells, with inhibitions over 100%. Overall, Thiamphenicol has diverse pharmacological effects on multiple biological pathways and targets, suggesting its potential utility in various therapeutic areas, albeit with a cautionary note regarding its hepatotoxic and nephrotoxic potential..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Thiamphenicol (Dextrosulphenidol) is a methylsulfonyl analog of chloramphenicol. It is an antibiotic and immunosuppressive agent.
别名	甲砜霉素, Thiophenicol, Dextrosulphenidol

化学信息

分子量	356.22
分子式	C₁₂H₁₅Cl₂NO₅S
CAS No.	15318-45-3
Smiles	[C@@H]([C@H](NC(C(Cl)Cl)=O)CO)(O)C1=CC=C(S(C)(=O)=O)C=C1
密度	1.3281 g/cm3 (Estimated)

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (154.4 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.61 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8073 mL	14.0363 mL	28.0725 mL	140.3627 mL
5 mM	0.5615 mL	2.8073 mL	5.6145 mL	28.0725 mL
10 mM	0.2807 mL	1.4036 mL	2.8073 mL	14.0363 mL
20 mM	0.1404 mL	0.7018 mL	1.4036 mL	7.0181 mL
50 mM	0.0561 mL	0.2807 mL	0.5615 mL	2.8073 mL
100 mM	0.0281 mL	0.1404 mL	0.2807 mL	1.4036 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

β-lactamase veterinary Thiamphenicol ribosomal post-antibiotic methyl-sulfonyl Inhibitor inhibit effect Bacterial Antibiotic 50S

Thiamphenicol

Thiamphenicol

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体内实验配液计算器

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