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Etomoxir

产品编号 T4535L CAS 124083-20-1

别名: (R)-(+)-Etomoxir

Etomoxir 是肉碱棕榈酰转移酶 1a （CPT-1a）抑制剂，通过抑制 CPT-1a 来抑制脂肪酸氧化，且抑制人、大鼠和豚鼠中棕榈酸酯的氧化。Etomoxir 对腺嘌呤核苷酸转位酶有抑制作用，可通过破坏CoA稳态来抑制巨噬细胞极化。

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Etomoxir, CAS 124083-20-1

规格	价格/CNY	货期
1 mg	￥ 281	现货
5 mg	￥ 663	现货
10 mg	￥ 1,230	现货
25 mg	￥ 2,420	现货
50 mg	￥ 3,590	现货
100 mg	￥ 5,190	现货
1 mL * 10 mM (in DMSO)	￥ 728	现货

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其他形式的 Etomoxir:

Etomoxir sodium salt
现货
S-(-)-Etomoxir
询价

选择批次

纯度: 99.39%

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	Etomoxir is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation by inhibiting CPT-1a and inhibits palmitate oxidation in humans, rats, and guinea pigs. Etomoxir has an inhibitory effect on adenine nucleotide translocase and can inhibit macrophage polarization by disrupting CoA homeostasis.
体外活性	Etomoxir irreversibly binds to the catalytic site of CPT-1, inhibiting its activity but also upregulating fatty acid oxidase. Etomoxir was developed as an inhibitor of mitochondrial carnitine palmitoyltransferase-1 (CPT-1), which is located on the outer membrane of the mitochondria. Etomoxir, acts as a peroxisome proliferator in the liver, increasing DNA synthesis and liver growth. Therefore, in addition to being a CPT1 inhibitor, etomoclax can also be considered a PPARalpha agonist[1]. Etomoxir is a member of the ethylene oxide carboxylate carnitine palmitoyltransferase I inhibitor family and has been suggested as an inhibitor against heart failure. Acute Etomoxir treatment irreversibly inhibits carnitine palmitoyltransferase I activity. As a result, fatty acid import into mitochondria and β-oxidation are reduced, whereas cytosolic fatty acid accumulation and glucose oxidation are increased. Prolonged incubation (24 hours) with Etomoxir produces differential effects on the expression of several metabolic enzymes.[1]
体内活性	Rats were injected with Etomoxir, daily for 8 days at a dose of 20 mg/kg body weight. Etomoxir-treated rats showed a 44% reduction in cardiac CPT-I activity. Treatment of Lewis rats with 20 mg/kg Etomoxir for 8 days did not alter blood glucose levels, consistent with similar Etomoxir feeding studies. Likewise, Etomoxir feeding did not affect general growth characteristics such as weight gain, nor did it affect hindlimb muscle mass. However, in Etomoxir-treated rats, both heart mass and liver mass were significantly increased by 11%.[3] Etomoxir is an inhibitor of CPT1, a key enzyme involved in free fatty acid (FFA) oxidation. P53 directly interacts with Bax and Bax is inhibited by Etomoxir, further confirming the direct interaction of P53 and Bax and the involvement of FAO-mediated mitochondrial ROS generation in db/db mice.[2]

别名	(R)-(+)-Etomoxir
分子量	326.82
分子式	C17H23ClO4
CAS No.	124083-20-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 32.68 mg/mL (100 mM), Sonication and heating are recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0598 mL	15.2989 mL	30.5979 mL	76.4947 mL
	5 mM	0.612 mL	3.0598 mL	6.1196 mL	15.2989 mL
	10 mM	0.306 mL	1.5299 mL	3.0598 mL	7.6495 mL
	20 mM	0.153 mL	0.7649 mL	1.5299 mL	3.8247 mL
	50 mM	0.0612 mL	0.306 mL	0.612 mL	1.5299 mL
	100 mM	0.0306 mL	0.153 mL	0.306 mL	0.7649 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Xu FY, et al. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res. 2003 Feb;44(2):415-23. 2. Li J, et al. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Sci Rep. 2015 Jul 31;5:12724. 3. Luiken JJ, et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates. Biochem J. 2009 Apr 15;419(2):447-55. 4. O'Connor RS, et al. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Sci Rep. 2018 Apr 19;8(1):6289.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Etomoxir 124083-20-1 Metabolism oxidation-reduction Antioxidant CPT (R)-(+)-Etomoxir Inhibitor inhibitor inhibit

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Etomoxir

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

相关产品

相关化合物库

剂量换算

体内实验配液计算器

技术支持

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