很棒
U93631 是一种具有新型化学结构的 GABAA 受体配体，IC50 为 100 nM，它在重组 GABAA 受体中诱导 GABA 诱导的全细胞 Cl 电流快速，这种效果随时间依赖性衰减。
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很棒U93631 是一种具有新型化学结构的 GABAA 受体配体，IC50 为 100 nM，它在重组 GABAA 受体中诱导 GABA 诱导的全细胞 Cl 电流快速，这种效果随时间依赖性衰减。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 136 | 现货 | |
| 5 mg | ¥ 223 | 现货 | |
| 10 mg | ¥ 323 | 现货 | |
| 25 mg | ¥ 642 | 现货 | |
| 50 mg | ¥ 987 | 现货 | |
| 100 mg | ¥ 1,720 | 现货 | |
| 200 mg | ¥ 2,490 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 273 | 现货 |
| 产品描述 | GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism. |
| 靶点活性 | GABAA:100 nM |
| 体外活性 | In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization, rather than acting as an open channel blocker. |
| 分子量 | 299.37 |
| 分子式 | C17H21N3O2 |
| CAS No. | 152273-12-6 |
| Smiles | CC(C)(C)OC(=O)c1ncn-2c1C(C)(C)Nc1ccccc-21 |
| 密度 | 1.19g/cm3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 55 mg/mL (183.72 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 一共给药动物 10 只 ，您使用的配方为 5% 
DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为 2 mg/mL 。 母液，添加 300 μLPEG300 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2O 混匀澄清 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
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