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Anti-Serpin D1 Antibody (6A450)
还可以产品编号 TMAY-00572
Anti-Serpin D1 Antibody (6A450) 是一种 Mouse 抗体，靶向 Serpin D1。Anti-Serpin D1 Antibody (6A450) 可用于 IHC-P。
Anti-Serpin D1 Antibody (6A450)
Anti-Serpin D1 Antibody (6A450)
还可以产品编号 TMAY-00572
Anti-Serpin D1 Antibody (6A450) 是一种 Mouse 抗体，靶向 Serpin D1。Anti-Serpin D1 Antibody (6A450) 可用于 IHC-P。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-Serpin D1 Antibody (6A450) is a Mouse antibody targeting Serpin D1. Anti-Serpin D1 Antibody (6A450) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6A450 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human serpinD1 in human liver with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte. 2. Immunochemical staining of human serpinD1 in human hepatoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinD1 (rh SerpinD1; TMPY-00917; NP_000176.2; Met1-Ser499). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human SerpinD1 protein (TMPY-00917) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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