规格

价格

库存

数量

1 mg

¥ 131

现货

5 mg

¥ 297

现货

10 mg

¥ 475

现货

25 mg

¥ 1,000

现货

50 mg

¥ 1,600

现货

100 mg

¥ 2,390

现货

200 mg

¥ 3,390

现货

1 mL x 10 mM (in DMSO)

¥ 328

现货

生物活性

产品描述	D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit.
体外活性	D159687 在处理后6小时达到峰值，引起CREB磷酸化的瞬时增加（F（3, 20）= 3.731，P = 0.0425）。在1μM浓度下，CREB磷酸化达到最佳（F（3, 20）= 4.194，P = 0.0302）。
细胞实验	cAMP concentrations were measured using the enzyme-linked immunosorbent assay.?On the day of treatment, the attached HT-22 cells were washed with warm phosphate buffer saline and then incubated for 10 min with PBS supplemented with various concentrations of D159687 and further for 10 min with 10 nM isoproterenol in the system52.?After incubation, PBS containing the drugs was removed and the plates were let dry roughly before 200 μl HCl (0.1 M) was added to each well to lyse the cells.?Cell lysates were collected into Eppendorf tubes and centrifuged at 800 g for 15 min. Supernatants were collected for immediate assay or stored frozen for assay later using the cAMP complete ELISA kit according to the assay protocol.
别名	D 159687

化学信息

分子量	366.84
分子式	C₂₁H₁₉ClN₂O₂
CAS No.	1155877-97-6
Smiles	COc1ccc(Cc2ccc(NC(N)=O)cc2)cc1-c1cccc(Cl)c1
密度	1.263 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 150 mg/mL (408.9 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.9 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO