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Dichlorisone Acetate

Name: Dichlorisone Acetate
Brand: TargetMol
SKU: T0269
Price: 4850 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.51%

货号 T0269Cas号 79-61-8

别名 糊状叶绿素, 醋酸二氯松, Diloderm

Dichlorisone Acetate (Diloderm) 一种是合成的糖皮质激素皮质类固醇，具有抗炎特性。

Dichlorisone Acetate

一键复制产品信息

很棒

纯度: 99.51%

货号 T0269 别名 糊状叶绿素, 醋酸二氯松, DilodermCas号 79-61-8

Dichlorisone Acetate (Diloderm) 一种是合成的糖皮质激素皮质类固醇，具有抗炎特性。

规格	价格	库存
5 mg	¥ 4,850	现货
10 mg	¥ 7,750	现货
50 mg	¥ 21,780	待询

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.51%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Dichlorisone Acetate AI Summary

Dichlorisone Acetate exhibits a diverse range of bioactivities, acting as both an agonist and antagonist in various pathways. It demonstrates significant potency (5.0 nM) as both an agonist and antagonist for the Hypoxia Response Element Signaling Pathway, and functions as an inhibitor for DNA Polymerase Beta with a potency of 7943.3 nM. It also shows inhibitory effects on the Nrf2 pathway with potencies ranging from 29092.9 nM to 1299.5 nM, and on GCN5L2 with a potency of 19952.6 nM. Additionally, it induces synthetic lethality in tumor cells producing 2HG, with a potency of 4109.5 nM. In antiviral studies, Dichlorisone Acetate has shown activity against SARS-CoV-2. It exhibits antiviral effects by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours, with an inhibition rate of -2.77%. It also shows 14.46% inhibition of the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, and inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells with an IC50 value greater than 20,000 nM. Additionally, Dichlorisone Acetate displays binding affinity to human AR and PGR with AC50 values of 128.4 nM and 172.8 nM, respectively. It does not exhibit significant activity in inhibition assays against a variety of enzymes, and shows weak binding affinity to several receptors with AC50 values greater than 30,000 nM. However, it does exhibit antagonist activity at TBXA2R and ADRA1A, and agonist activity at HTR2B, ADRA1A, CHRM1, and TBXA2R, all with AC50 values greater than 30,000 nM. Overall, Dichlorisone Acetate interacts with a broad array of receptors and pathways, albeit with varying potency..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dichlorisone Acetate (Diloderm) is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
别名	糊状叶绿素, 醋酸二氯松, Diloderm

化学信息

分子量	455.37
分子式	C₂₃H₂₈Cl₂O₅
CAS No.	79-61-8
Smiles	CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)C=CC4(C)[C@@]3(Cl)C(Cl)CC12C
密度	1.34g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 4.56 mg/mL (10.01 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1960 mL	10.9801 mL	21.9602 mL	109.8008 mL
5 mM	0.4392 mL	2.1960 mL	4.3920 mL	21.9602 mL
10 mM	0.2196 mL	1.0980 mL	2.1960 mL	10.9801 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit EndogenousMetabolite Endogenous Metabolite Dichlorisone Acetate Dichlorisone AChE

Dichlorisone Acetate

Dichlorisone Acetate