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Dichlorisone Acetate

Name: Dichlorisone Acetate
Brand: TargetMol
SKU: T0269
Price: 186 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 糊状叶绿素, 醋酸二氯松, Diloderm

货号 T0269Cas号 79-61-8 一键复制产品信息纯度: 99.51%

很棒

Dichlorisone Acetate (Diloderm) 一种是合成的糖皮质激素皮质类固醇，具有抗炎特性。

Dichlorisone Acetate

一键复制产品信息

很棒

纯度: 99.51%

货号 T0269Cas号 79-61-8

别名 糊状叶绿素, 醋酸二氯松, Diloderm

Dichlorisone Acetate (Diloderm) 一种是合成的糖皮质激素皮质类固醇，具有抗炎特性。

规格	价格	库存
1 mg	¥ 186	现货
5 mg	¥ 413	现货
10 mg	¥ 662	现货
25 mg	¥ 1,090	现货
50 mg	¥ 1,650	待询
100 mg	¥ 2,460	待询

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.51%

颜色: 白色

性状: Solid

资源下载: COA HNMR HPLC产品操作手册

产品介绍

Dichlorisone Acetate AI Summary

Dichlorisone Acetate exhibits a diverse range of bioactivities, acting as both an agonist and antagonist in various pathways. It demonstrates significant potency (5.0 nM) as both an agonist and antagonist for the Hypoxia Response Element Signaling Pathway, and functions as an inhibitor for DNA Polymerase Beta with a potency of 7943.3 nM. It also shows inhibitory effects on the Nrf2 pathway with potencies ranging from 29092.9 nM to 1299.5 nM, and on GCN5L2 with a potency of 19952.6 nM. Additionally, it induces synthetic lethality in tumor cells producing 2HG, with a potency of 4109.5 nM. In antiviral studies, Dichlorisone Acetate has shown activity against SARS-CoV-2. It exhibits antiviral effects by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours, with an inhibition rate of -2.77%. It also shows 14.46% inhibition of the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, and inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells with an IC50 value greater than 20,000 nM. Additionally, Dichlorisone Acetate displays binding affinity to human AR and PGR with AC50 values of 128.4 nM and 172.8 nM, respectively. It does not exhibit significant activity in inhibition assays against a variety of enzymes, and shows weak binding affinity to several receptors with AC50 values greater than 30,000 nM. However, it does exhibit antagonist activity at TBXA2R and ADRA1A, and agonist activity at HTR2B, ADRA1A, CHRM1, and TBXA2R, all with AC50 values greater than 30,000 nM. Overall, Dichlorisone Acetate interacts with a broad array of receptors and pathways, albeit with varying potency..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dichlorisone Acetate (Diloderm) is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
别名	糊状叶绿素, 醋酸二氯松, Diloderm

化学信息

分子量	455.37
分子式	C₂₃H₂₈Cl₂O₅
CAS No.	79-61-8
Smiles	CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)C=CC4(C)[C@@]3(Cl)C(Cl)CC12C
密度	1.34g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 4.56 mg/mL (10.01 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1960 mL	10.9801 mL	21.9602 mL	109.8008 mL
5 mM	0.4392 mL	2.1960 mL	4.3920 mL	21.9602 mL
10 mM	0.2196 mL	1.0980 mL	2.1960 mL	10.9801 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。