Hemicholinium 3

Name: Hemicholinium 3
Brand: TargetMol
SKU: T2227
Price: 245 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.95%

货号 T2227Cas号 312-45-8

别名 半胆碱基-3, Hemicholinium-3, Hemicholine

Hemicholinium 3 是一种竞争性的、高亲和力的胆碱转运蛋白 (HACU) 抑制剂，Ki=25 nM。它是一种神经肌肉阻滞剂，能够抑制乙酰胆碱 (ACh)的合成和释放。它抑制Epibatidine 诱发的收缩和 [3H] 乙酰胆碱释放，IC50分别为 897 nM 和 693 nM。

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Hemicholinium 3

一键复制产品信息

很棒

纯度: 99.95%

货号 T2227 别名 半胆碱基-3, Hemicholinium-3, HemicholineCas号 312-45-8

规格	价格	库存
5 mg	¥ 245	现货
10 mg	¥ 393	现货
25 mg	¥ 747	现货
50 mg	¥ 1,180	现货
1 mL x 10 mM (in DMSO)	¥ 329	现货

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产品介绍

Hemicholinium 3 AI Summary

Hemicholinium 3 exhibits a diverse range of bioactivities. It is a potent inhibitor of the Acetylcholine transporter, with an IC50 value of 12.0 nM. Additionally, it inhibits the choline transporter in human PC-3 cells with an IC50 value of 36000.0 nM. Hemicholinium 3 also shows efficacy in inhibiting the proliferation of Plasmodium falciparum lines and various human enzymes such as JMJD2E, ALDH1A1, DNA Polymerase Beta, and Histone Lysine Methyltransferase G9a. It affects malarial parasite plastid, lipid storage, induces DNA re-replication in MCF 10a and SW480 cell lines, and has activity against DNA helicase RECQ1, polymerase iota, HCV, TDP-43, RAD52, and human APE1. Toxicity studies indicate that Hemicholinium 3 has an LD50 of 0.13 mg/kg and an LD95 of 0.2 mg/kg when administered intraperitoneally to CD-1 mice, with mortality rates influenced by co-administration of choline and neostigmine. Furthermore, the compound exhibits a low level of activity in inhibiting the cell viability of Vero E6 cells infected with SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Hemicholinium 3 is a potent and selective choline uptake blocker.
别名	半胆碱基-3, Hemicholinium-3, Hemicholine

化学信息

分子量	574.35
分子式	C₂₄H₃₄Br₂N₂O₄
CAS No.	312-45-8
Smiles	[Br-].[Br-].C[N+]1(C)CCOC(O)(C1)c1ccc(cc1)-c1ccc(cc1)C1(O)C[N+](C)(C)CCO1
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (87.05 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7411 mL	8.7055 mL	17.4110 mL	87.0549 mL
5 mM	0.3482 mL	1.7411 mL	3.4822 mL	17.4110 mL
10 mM	0.1741 mL	0.8705 mL	1.7411 mL	8.7055 mL
20 mM	0.0871 mL	0.4353 mL	0.8705 mL	4.3527 mL
50 mM	0.0348 mL	0.1741 mL	0.3482 mL	1.7411 mL