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NSC 23766是一种Rac1 GTPase抑制剂,通过靶向鸟嘌呤核苷酸交换因子(GEFs)抑制Rac1的激活,同时对紧密相关的靶点Cdc42和RhoA没有抑制作用,影响细胞周期和抑制细胞增殖,具有剂量依赖性。它还能够调节内皮NO合酶表达和内皮功能,抑制血小板聚集和γ-分泌酶活性。NSC23766能够竞争性的抑制M2毒蕈碱乙酰胆碱受体(M2 mAChR)诱导的新生大鼠心肌细胞中Rac1的激活。
NSC 23766是一种Rac1 GTPase抑制剂,通过靶向鸟嘌呤核苷酸交换因子(GEFs)抑制Rac1的激活,同时对紧密相关的靶点Cdc42和RhoA没有抑制作用,影响细胞周期和抑制细胞增殖,具有剂量依赖性。它还能够调节内皮NO合酶表达和内皮功能,抑制血小板聚集和γ-分泌酶活性。NSC23766能够竞争性的抑制M2毒蕈碱乙酰胆碱受体(M2 mAChR)诱导的新生大鼠心肌细胞中Rac1的激活。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 252 | 现货 |
产品描述 | NSC 23766 is a Rac1 GTPase inhibitor that inhibits Rac1 activation by targeting guanine nucleotide exchange factors (GEFs), while it has no inhibitory effect on the closely related targets Cdc42 and RhoA, affecting the cell cycle and inhibiting cell proliferation in a dose-dependent manner. It also regulates endothelial NO synthase expression and endothelial function, and inhibits platelet aggregation and γ-secretase activity.NSC23766 competitively inhibits M2 muscarinic acetylcholine receptor (M2 mAChR)-induced Rac1 activation in neonatal rat cardiomyocytes. |
体外活性 | NSC 23766 (200 μM) 处理卵母细胞,增加了卵母细胞形态异常纺锤体的百分比,并且p-MAPK 蛋白表达显著降低。[2] |
体内活性 | NSC 23766(2.5 mg/kg/天,腹腔注射)处理NOD 小鼠,显著减缓了 NOD 小鼠自发性糖尿病的发病,且对小鼠的生长(体重)无显著影响。[1] |
别名 | NSC23766 |
分子量 | 421.58 |
分子式 | C24H35N7 |
CAS No. | 733767-34-5 |
Smiles | N=1C(=NC(=CC1NC=2C=CC=3N=C(C=C(N)C3C2)C)C)NC(C)CCCN(CC)CC |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 80 mg/mL (189.76 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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