购物车

您的购物车当前为空

BuChE-IN-TM-10

Name: BuChE-IN-TM-10
Brand: TargetMol
SKU: T10630
Price: 1290 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: TM-10

货号 T10630Cas号 2313524-95-5 一键复制产品信息纯度: 99.54%

很棒

BuChE-IN-TM-10 (TM-10) 是一种有效的丁基胆碱酯酶 (BuChE) 抑制剂，其IC50 值为8.9 nM。BuChE inhibitor 1能够抑制和分解自诱导的Aβ聚合, 表现出强大的抗氧化活性和良好的血脑屏障 (BBB) 渗透性。可用于阿尔兹海默症的研究。

BuChE-IN-TM-10

一键复制产品信息

很棒

纯度: 99.54%

货号 T10630Cas号 2313524-95-5

别名 TM-10

规格	价格	库存
1 mg	¥ 1,290	现货
2 mg	¥ 1,930	现货
5 mg	¥ 2,990	现货
10 mg	¥ 4,390	现货
25 mg	¥ 6,910	现货
50 mg	¥ 9,490	现货
100 mg	¥ 12,800	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.54%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

BuChE-IN-TM-10 AI Summary

BuChE-IN-TM-10 demonstrates a range of bioactivities, including the inhibition of various enzymes and effects on amyloid beta aggregation. Specifically, it inhibits equine serum butyrylcholinesterase (BChE) with an IC50 of 8.9 nM and electric eel acetylcholinesterase (AChE) with an IC50 of 12100.0 nM. Additionally, it inhibits human monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC50 values of 6300.0 nM and 8600.0 nM, respectively. The compound also inhibits an unidentified source of BChE with an IC50 of 8900.0 nM. It exhibits significant activity against amyloid beta aggregation, inhibiting self-induced amyloid beta (1-42) aggregation by 53.9% at a concentration of 25 μM and disaggregating pre-formed amyloid beta aggregates by 43.8% at the same concentration. Furthermore, BuChE-IN-TM-10 has demonstrated antioxidant activity comparable to 0.53 trolox in the ORAC radical scavenging assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BuChE-IN-TM-10 (TM-10) is a potent inhibitor of butyrylcholinesterase (BuChE), exhibiting an IC50 of 8.9 nM. It effectively inhibits and disaggregates self-induced Aβ aggregation, displays significant antioxidant activity, and demonstrates substantial penetration through the blood-brain barrier (BBB). TM-10 holds promise as a potential treatment for Alzheimer’s disease.
靶点活性	BuChE:8.9 nM
别名	TM-10

化学信息

分子量	498.66
分子式	C₃₂H₃₈N₂O₃
CAS No.	2313524-95-5
Smiles	C(/C=C/C1=CC(OC)=C(OCCCCN(CC2=CC=CC=C2)CC)C=C1)(=O)N3CC=4C(CC3)=CC=CC4
密度	1.127 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 5.48 mg/mL (10.99 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0054 mL	10.0269 mL	20.0537 mL	100.2687 mL
5 mM	0.4011 mL	2.0054 mL	4.0107 mL	20.0537 mL
10 mM	0.2005 mL	1.0027 mL	2.0054 mL	10.0269 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。