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MDL-28170

Name: MDL-28170
Brand: TargetMol
SKU: T2470
Price: 297 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 95.06%

货号 T2470Cas号 88191-84-8

别名 Calpain Inhibitor III

MDL-28170 (Calpain Inhibitor III) 是一种选择性的、有效的、具有膜渗透性的半胱氨酸蛋白酶 (calpain)抑制剂，可在全身给药后迅速穿过血脑屏障。它还能阻断γ-secretase。

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MDL-28170

一键复制产品信息

很棒

纯度: 95.06%

货号 T2470 别名 Calpain Inhibitor IIICas号 88191-84-8

规格	价格	库存
1 mg	¥ 297	现货
2 mg	¥ 423	现货
5 mg	¥ 645	现货
10 mg	¥ 927	现货
25 mg	¥ 1,990	现货
50 mg	¥ 3,570	现货
100 mg	¥ 5,190	现货
500 mg	¥ 10,900	现货
1 mL x 10 mM (in DMSO)	¥ 728	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 95.06%

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COA LCMS HNMR 产品操作手册

产品介绍

MDL-28170 AI Summary

MDL-28170 is a multifaceted inhibitor prominently known for its effectiveness against various calpain enzymes and other proteases. It inhibits human calpain 1, mu-calpain, with IC50 values ranging between 11.0 nM to 200.0 nM, exhibiting a high affinity with Ki values as low as 10.0 nM. The compound also inhibits cathepsin B (IC50 = 95.8 nM), cathepsin L (IC50 = 3.1 nM), and cathepsin H and D weakly. Additionally, MDL-28170 demonstrates significant inhibitory activity against the degradation of tyrosine kinase pp60src by calpain in human platelets, with an IC50 of 700.0 nM. In other bioactivities, it shows antiplasmodial effects against Plasmodium falciparum with varying IC50 values and exhibits antiviral activity against SARS-CoV in HEK293 cells expressing human ACE2 with an EC50 of 100.0 nM. This compound also has been noted for its inhibition of histone lysine methyltransferase G9a, AmpC beta-lactamase, malaria parasite plastid, and other enzymes, although with lesser potency. It represents a versatile bioactive compound with potential therapeutic implications across various diseases and conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.
别名	Calpain Inhibitor III

化学信息

分子量	382.45
分子式	C₂₂H₂₆N₂O₄
CAS No.	88191-84-8
Smiles	CC(C)C(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C=O
密度	1.153 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (130.74 mM), Sonication and heating are recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.23 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6147 mL	13.0736 mL	26.1472 mL	130.7360 mL
5 mM	0.5229 mL	2.6147 mL	5.2294 mL	26.1472 mL
10 mM	0.2615 mL	1.3074 mL	2.6147 mL	13.0736 mL
20 mM	0.1307 mL	0.6537 mL	1.3074 mL	6.5368 mL
50 mM	0.0523 mL	0.2615 mL	0.5229 mL	2.6147 mL
100 mM	0.0261 mL	0.1307 mL	0.2615 mL	1.3074 mL