Minaprine dihydrochloride

Name: Minaprine dihydrochloride
Brand: TargetMol
SKU: T8907
Price: 122 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.99%

货号 T8907Cas号 25953-17-7

别名 米那卜林二盐酸盐

Minaprine dihydrochloride 是一种可逆的单胺氧化酶 MAO-A 抑制剂，对乙酰胆碱酯酶有微弱抑制，是一种抗抑郁类化合物。

Minaprine dihydrochloride

一键复制产品信息

很棒

纯度: 99.99%

货号 T8907 别名 米那卜林二盐酸盐Cas号 25953-17-7

Minaprine dihydrochloride 是一种可逆的单胺氧化酶 MAO-A 抑制剂，对乙酰胆碱酯酶有微弱抑制，是一种抗抑郁类化合物。

规格	价格	库存
50 mg	¥ 196	现货
100 mg	¥ 289	现货
1 mL x 10 mM (in DMSO)	¥ 122	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.99%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Minaprine dihydrochloride AI Summary

Minaprine dihydrochloride shows multifaceted bioactivity, including effects on cytochrome P450 3A4, where it can act as both an activator and an inhibitor or substrate. This implicates potential influences on drug metabolism pathways mediated by cytochrome P450 enzymes. Additionally, it demonstrates potency in a Schwann cell assay involving the PMP22 intronic element, suggesting a role in Schwann cell function. In virological contexts, Minaprine dihydrochloride exhibits antiviral properties. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a concentration of 10 µM after 48 hours and in VERO-6 cells at a similar concentration and duration, though the inhibition rate in VERO-6 cells is low at 0.03%. Moreover, it inhibits SARS-CoV-2 3CL-Pro protease by 25.46% at a concentration of 20 µM. However, Minaprine dihydrochloride shows a low inhibition index value of 0.2144 for cell viability in Vero E6 cells infected with SARS-CoV-2, suggesting limited bioactivity in this specific assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Minaprine dihydrochloride is a reversible MAO-A inhibitor; It weakly inhibit acetylcholinesterase. Minaprine dihydrochloride is an antidepressant for treatment of depression.
别名	米那卜林二盐酸盐

化学信息

分子量	371.3
分子式	C₁₇H₂₄Cl₂N₄O
CAS No.	25953-17-7
Smiles	Cl.Cl.Cc1cc(nnc1NCCN1CCOCC1)-c1ccccc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (134.66 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.39 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6932 mL	13.4662 mL	26.9324 mL	134.6620 mL
5 mM	0.5386 mL	2.6932 mL	5.3865 mL	26.9324 mL
10 mM	0.2693 mL	1.3466 mL	2.6932 mL	13.4662 mL
20 mM	0.1347 mL	0.6733 mL	1.3466 mL	6.7331 mL
50 mM	0.0539 mL	0.2693 mL	0.5386 mL	2.6932 mL
100 mM	0.0269 mL	0.1347 mL	0.2693 mL	1.3466 mL