lavendustin C

Name: lavendustin C
Brand: TargetMol
SKU: T4185
Price: 393 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.06%

货号 T4185Cas号 125697-93-0

别名 NSC 666251, N-(2,5-二羟基苄基)-5-氨基水杨酸, HDBA

lavendustin C (NSC 666251) 是 Ca2+钙调蛋白依赖性激酶 II 抑制剂，IC50为 0.2 µM。它抑制 EGFR 相关酪氨酸激酶和 pp60c-src(+)激酶，IC50分别为 0.012 和 0.5 µM。

lavendustin C

一键复制产品信息

很棒

纯度: 98.06%

货号 T4185 别名 NSC 666251, N-(2,5-二羟基苄基)-5-氨基水杨酸, HDBACas号 125697-93-0

lavendustin C (NSC 666251) 是 Ca2+钙调蛋白依赖性激酶 II 抑制剂，IC50为 0.2 µM。它抑制 EGFR 相关酪氨酸激酶和 pp60c-src(+)激酶，IC50分别为 0.012 和 0.5 µM。

规格	价格	库存
1 mg	¥ 393	现货
5 mg	¥ 916	现货
10 mg	¥ 1,550	现货
25 mg	¥ 3,280	现货
50 mg	¥ 4,690	现货
100 mg	¥ 6,550	现货
1 mL x 10 mM (in DMSO)	¥ 857	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.06%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

lavendustin C AI Summary

lavendustin C exhibits a diverse range of bioactivities with significant potency as an inhibitor of several protein tyrosine kinases. It shows an IC50 of 30.0 nM for inhibition of tyrosine kinase activity by competing with the RRSrc peptide and an IC50 of 4,000 nM for inhibiting epidermal growth factor receptor (EGFR) autophosphorylation. Additionally, it inhibits p56lck autophosphorylation and protein-tyrosine kinase p56lck with IC50 values of 10,000 nM. Besides its kinase inhibitory activity, it affects EGF-dependent DNA synthesis in ER22 cells with an IC50 of 92,000 nM and expresses cytotoxicity against human HaCaT and HEK293 cells with IC50 values greater than 100,000 nM. lavendustin C also impacts NOX4 activity in HEK293 FS cells, inhibiting H2O2 production with an IC50 of 1,340 nM. Furthermore, it demonstrates inhibitory activity against various other biological targets, offering potential for broad-spectrum therapeutic applications in nanomolar to micromolar potency ranges..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
靶点活性	CaMK II:0.2 μM (IC50), EGFR:0.012 μM (IC50)
别名	NSC 666251, N-(2,5-二羟基苄基)-5-氨基水杨酸, HDBA

化学信息

分子量	275.26
分子式	C₁₄H₁₃NO₅
CAS No.	125697-93-0
Smiles	N(CC1=C(O)C=CC(O)=C1)C2=CC(C(O)=O)=C(O)C=C2
密度	1.551 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (217.98 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.27 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6329 mL	18.1646 mL	36.3293 mL	181.6464 mL
5 mM	0.7266 mL	3.6329 mL	7.2659 mL	36.3293 mL
10 mM	0.3633 mL	1.8165 mL	3.6329 mL	18.1646 mL
20 mM	0.1816 mL	0.9082 mL	1.8165 mL	9.0823 mL
50 mM	0.0727 mL	0.3633 mL	0.7266 mL	3.6329 mL
100 mM	0.0363 mL	0.1816 mL	0.3633 mL	1.8165 mL