S65487 hydrochloride

Name: S65487 hydrochloride
Brand: TargetMol
SKU: T39135
Rating: 4.5 (1 reviews)

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产品编号 T39135Cas号 1644543-95-2

别名 VOB560 hydrochloride, S65487 hydrochloride

S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y. It exhibits poor affinity for MCL-1, BFL-1, and BCL-XL. This compound induces apoptosis and possesses anticancer activities.

S65487 hydrochloride

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产品编号 T39135 别名 VOB560 hydrochloride, S65487 hydrochlorideCas号 1644543-95-2

规格	价格	库存	数量
10 mg	¥ 6,990	6-8周
25 mg	¥ 14,900	6-8周

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产品描述	S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y. It exhibits poor affinity for MCL-1, BFL-1, and BCL-XL. This compound induces apoptosis and possesses anticancer activities.
体外活性	S65487 hydrochloride binds to the BH3 hydrophobic groove of BCL-2. S65487 hydrochloride induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC 50 s in the low nM range[1].
体内活性	S65487 hydrochloride induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat are observed at well tolerated doses following weekly IV administration of S65487 hydrochloride in combination with the MCL-1-specific inhibitor, S64315/MIK665[1].
别名	VOB560 hydrochloride, S65487 hydrochloride