JTK-853

Name: JTK-853
Brand: TargetMol
SKU: T15631
Rating: 4.5 (1 reviews)

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产品编号 T15631Cas号 954389-09-4

JTK-853 is a novel, non-nucleoside inhibitor of Hepatitis C Virus (HCV) polymerase. It also displays effective antiviral activity in HCV replicon cells (EC50s: 0.38 and 0.035 μM in genotype 1a H77 and 1b Con1 strains, respectively).

JTK-853

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产品编号 T15631Cas号 954389-09-4

规格	价格	库存
25 mg	¥ 37,400	8-10周
50 mg	¥ 48,700	8-10周
100 mg	¥ 62,980	8-10周

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产品介绍

生物活性

产品描述	JTK-853 is a novel, non-nucleoside inhibitor of Hepatitis C Virus (HCV) polymerase. It also displays effective antiviral activity in HCV replicon cells (EC50s: 0.38 and 0.035 μM in genotype 1a H77 and 1b Con1 strains, respectively).
靶点活性	HCV 1a H77:(EC50)0.38 μM, HCV 1b Con1:0.035 μM
体外活性	JTK-853 inhibits the drug-resistant colony formation in the genotype 1a replicon cells, and the numbers of JTK-853-resistant colonies are much lower than those of GS-9190-resistant colonies for both genotypes. When JTK-853 is incubated with the replicon cells for 48 h, it shows antiviral activity against genotype 1a H77 and 1b Con1 replicon cells (EC90: 6.5±0.5 and 0.34±0.05 μM, respectively). In 2-week culture, JTK-853(at 10 μM) causes apparent Huh-7.5 cell death[1].