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Phenytoin sodium

Name: Phenytoin sodium
Brand: TargetMol
SKU: T0008
Price: 333 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.92%

货号 T0008Cas号 630-93-3

别名 苯妥英钠, Diphenylhydantoin Sodium, Diphantoine, Dilantin sodium, 5,5-Diphenylhydantoin sodium salt

Phenytoin sodium (Diphantoine) 是一种有效的电压门控钠离子通道阻滞剂，可减少小鼠乳腺肿瘤的生长和转移，具有抗癫痫活性。

Phenytoin sodium

一键复制产品信息

很棒

纯度: 99.92%

货号 T0008 别名 苯妥英钠, Diphenylhydantoin Sodium, Diphantoine, Dilantin sodium, 5,5-Diphenylhydantoin sodium saltCas号 630-93-3

Phenytoin sodium (Diphantoine) 是一种有效的电压门控钠离子通道阻滞剂，可减少小鼠乳腺肿瘤的生长和转移，具有抗癫痫活性。

规格	价格	库存
500 mg	¥ 333	现货
1 g	¥ 418	现货
5 g	¥ 671	现货
1 mL x 10 mM (in DMSO)	¥ 418	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.92%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

生物活性

产品描述	Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .
别名	苯妥英钠, Diphenylhydantoin Sodium, Diphantoine, Dilantin sodium, 5,5-Diphenylhydantoin sodium salt

化学信息

分子量	274.25
分子式	C₁₅H₁₁N₂NaO₂
CAS No.	630-93-3
Smiles	[Na+].O=C1NC(C(=O)[N-]1)(c1ccccc1)c1ccccc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 9 mg/mL (32.82 mM), Sonication is recommended.

DMSO: 13.16 mg/mL (47.99 mM), Sonication is recommended.

H2O: 3 mg/mL (10.94 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.65 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6463 mL	18.2315 mL	36.4631 mL	182.3154 mL
5 mM	0.7293 mL	3.6463 mL	7.2926 mL	36.4631 mL
10 mM	0.3646 mL	1.8232 mL	3.6463 mL	18.2315 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1823 mL	0.9116 mL	1.8232 mL	9.1158 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Phenytoin sodium exhibits a diverse range of bioactivities, prominently including cognitive enhancement, anticonvulsant properties, and antiviral effects. It demonstrates cognitive activity by improving passive avoidance learning in mice at lower doses (1.25 mg/kg to 5 mg/kg) with retention rates ranging from 75.0% to 90.0%, but higher doses (10 mg/kg to 80 mg/kg) result in decreased retention rates from 15.0% to 55.0%. As an anticonvulsant, it shows efficacy across various models: in mice and rats, it inhibits maximal electroshock-induced seizures with significant protection rates at doses between 7.5 mg/kg and 50 mg/kg, and displays activity in pentylenetetrazole-induced seizure models. At the antiviral level, it inhibits SARS-CoV-2 induced cytotoxicity and the SARS-CoV-2 3CL-Pro protease. Additionally, it is effective against influenza NS1 protein function and Lassa virus. The compound also interferes with various other biological targets such as the MLL CXXC domain - DNA interaction, cytochrome P450 2C9, and acetylcholine muscarinic M1 receptor, and shows broad antimicrobial activity against fungal species like Candida albicans and Cryptococcus neoformans, and bacterial strains including E. coli and Staphylococcus aureus MRSA. However, it exhibits neurotoxicity with low TD50 values in rotarod tests, indicating a moderate margin of safety between its therapeutic and toxic doses. The compound has an estimated ALD50 of 1000 mg/kg in rats, suggesting a relatively high acute toxicity threshold..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl