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Levolansoprazole

Name: Levolansoprazole
Brand: TargetMol
SKU: T20714
Price: 1150 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.62%

货号 T20714Cas号 138530-95-7

别名 左旋兰索拉唑, (S)-Lansoprazole, (-)-Lansoprazole

Levolansoprazole ((S)-Lansoprazole) 是一种质子泵抑制剂，不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成(IC50：82 µM)。 (R)-和 (S)-兰索拉唑均具有药理活性，具有相似的效力。

Levolansoprazole

一键复制产品信息

很棒

纯度: 98.62%

货号 T20714 别名 左旋兰索拉唑, (S)-Lansoprazole, (-)-LansoprazoleCas号 138530-95-7

规格	价格	库存
1 mg	¥ 1,150	现货
5 mg	¥ 2,590	现货
10 mg	¥ 3,630	现货
25 mg	¥ 5,820	现货
50 mg	¥ 7,830	现货
100 mg	¥ 10,500	现货
200 mg	¥ 14,200	现货
1 mL x 10 mM (in DMSO)	¥ 3,270	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.62%

颜色: 黄色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Levolansoprazole AI Summary

Levolansoprazole exhibits a broad range of biological activities and pharmacokinetic properties. It shows inhibitory activity against beta-lactamase, chymotrypsin, malate dehydrogenase (less than 5.0% inhibition), and various cytochrome P450 enzymes including CYP2C19, CYP2D6, CYP2C9, CYP1A2, and CYP2C8 with varying IC50 values. The compound has a lipophilicity of LogD6.5 = 1.73 and LogP = 1.47, a high plasma protein binding of 98.4%, and significant oral bioavailability (F ≥ 80.0%). Its pharmacokinetic profile includes a short half-life ranging from 0.06667 hours at pH 3 to 40.0 hours at pH 7.4, and a total body clearance of 4.4 mL.min-1.kg-1. It has a moderate volume of distribution at steady state (Vdss) of 0.35 L.kg-1 and a low fraction unbound in plasma (log Fu = 0.03). The compound's dissociation constants are pKa = 4.0 in pyridine and 8.78 in imidazole, indicating it can exhibit both acidic and basic properties. Levolansoprazole demonstrates gastroprotective activity in mice, reducing HCl/EtOH-induced gastric lesions by up to 80.0% at 20 mg/kg. It displays cytotoxicity against various human cell lines with IC50 values in the micromolar range. The compound shows antimicrobial activities against Plasmodium falciparum with IC50 values around 11000–12589.25 nM, and significant inhibitory effects against Trypanosoma cruzi (7.279% at 30 µM). It also exhibits antagonist activity at HRH2, DRD4, OPRK1, and other receptors. Notably, Levolansoprazole inhibits SARS-CoV-2 related enzymes and viral activity with an IC50 value of 1.607 µM for the 3CL-Pro protease. The compound shows antiviral effects, including against SARS-CoV-2-induced cytotoxicity in various cell lines. Additionally, it exhibits moderate liver toxicity, affecting liver enzyme levels and potentially causing drug-induced liver injury. Overall, Levolansoprazole has a complex profile of bioactivities, making it a candidate for further detailed pharmacological and toxicological studies to explore its therapeutic potential and safety profile..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Levolansoprazole ((S)-Lansoprazole), a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50: 5.2 μM). It also inhibits acid formation in isolated canine parietal cells (IC50: 82 μM). Both (R)- and (S)-lansoprazole are pharmacologically active with similar potencies.
别名	左旋兰索拉唑, (S)-Lansoprazole, (-)-Lansoprazole

化学信息

分子量	369.36
分子式	C₁₆H₁₄F₃N₃O₂S
CAS No.	138530-95-7
Smiles	S(CC1=C(C)C(OCC(F)(F)F)=CC=N1)(=O)C=2NC=3C(N2)=CC=CC3
密度	1.50 g/cm3 (Predicted)

储存&溶解度

存储

keep away from direct sunlight,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (148.91 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7074 mL	13.5369 mL	27.0739 mL	135.3693 mL
5 mM	0.5415 mL	2.7074 mL	5.4148 mL	27.0739 mL
10 mM	0.2707 mL	1.3537 mL	2.7074 mL	13.5369 mL
20 mM	0.1354 mL	0.6768 mL	1.3537 mL	6.7685 mL
50 mM	0.0541 mL	0.2707 mL	0.5415 mL	2.7074 mL
100 mM	0.0271 mL	0.1354 mL	0.2707 mL	1.3537 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Protonpump proton pump Levolansoprazole Lansoprazole

Levolansoprazole

Levolansoprazole