Imidazolidinyl urea

Name: Imidazolidinyl urea
Brand: TargetMol
SKU: T0430
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.6%

货号 T0430Cas号 39236-46-9

别名 咪唑烷基脲, Imidurea

Imidazolidinyl urea (Imidurea) 在化妆品中作为抗菌防腐剂, 也用作甲醛释放剂。

Imidazolidinyl urea

一键复制产品信息

很棒

纯度: 98.6%

货号 T0430 别名 咪唑烷基脲, ImidureaCas号 39236-46-9

Imidazolidinyl urea (Imidurea) 在化妆品中作为抗菌防腐剂, 也用作甲醛释放剂。

规格	价格	库存
500 mg	¥ 108	现货
1 g	¥ 147	现货
5 g	¥ 316	现货
10 g	¥ 455	现货
1 mL x 10 mM (in DMSO)	¥ 108	现货

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纯度: 98.6%

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产品介绍

Imidazolidinyl urea AI Summary

Imidazolidinyl urea exhibits a range of bioactivities in various assays. It shows inhibition against HIV-1 integrase, with an inhibition greater than 50.0% at 1 mM, and less than 50.0% at 200 µM and 25 µM. In a qHTS assay, it inhibited RanGTP induced Rango-Importin beta complex dissociation with a potency of 7.3 nM, acted as a delayed death inhibitor for the malarial parasite plastid with a potency of 18,526.0 nM, and inhibited HP1-beta Chromodomain interactions at 100,000.0 nM. In terms of antiviral activity, Imidazolidinyl urea inhibits SARS-CoV-2. It showed moderate bioactivity on infected Vero E6 cells with an inhibition index of 0.7579 compared to arbidol, and demonstrated 3.89% inhibition of virus-induced cytotoxicity in Caco-2 cells at 10 µM concentration over 48 hours. However, its activity against SARS-CoV-2 3CL-Pro protease was minimal, showing a 1.165% inhibition at 20 µM. The compound also inhibited transglutaminase in human keratinocytes by 35.0% in the presence of retinal, and likewise, inhibited human HDAC6 enzyme activity with rates of 38.7% and 7.67% using commercial and custom peptide substrates, respectively. This profile suggests its potential as both a HIV-1 integrase and HDAC6 inhibitor, as well as an antiviral agent with specific activities against SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Imidazolidinyl urea (Imidurea) is an antimicrobial preservative used in cosmetics.
别名	咪唑烷基脲, Imidurea

化学信息

分子量	388.29
分子式	C₁₁H₁₆N₈O₈
CAS No.	39236-46-9
Smiles	N(C(NCNC(NC1N(CO)C(=O)NC1=O)=O)=O)C2N(CO)C(=O)NC2=O
密度	1.85g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (643.85 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.15 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5754 mL	12.8770 mL	25.7539 mL	128.7697 mL
5 mM	0.5151 mL	2.5754 mL	5.1508 mL	25.7539 mL
10 mM	0.2575 mL	1.2877 mL	2.5754 mL	12.8770 mL
20 mM	0.1288 mL	0.6438 mL	1.2877 mL	6.4385 mL
50 mM	0.0515 mL	0.2575 mL	0.5151 mL	2.5754 mL
100 mM	0.0258 mL	0.1288 mL	0.2575 mL	1.2877 mL