Z-Glycine

Name: Z-Glycine
Brand: TargetMol
SKU: T33604
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.88%

货号 T33604Cas号 1138-80-3

别名 N-苄氧羰基-甘氨酸, N-Carbobenzoxyglycine, Carbobenzoxyglycine

Z-Glycine (Carbobenzoxyglycine) 是一种药物-脂质结合物，旨在促进脑渗透，基于其亲脂性和与生物膜中脂质的相似性。

Z-Glycine

一键复制产品信息

很棒

纯度: 99.88%

货号 T33604 别名 N-苄氧羰基-甘氨酸, N-Carbobenzoxyglycine, CarbobenzoxyglycineCas号 1138-80-3

Z-Glycine (Carbobenzoxyglycine) 是一种药物-脂质结合物，旨在促进脑渗透，基于其亲脂性和与生物膜中脂质的相似性。

规格	价格	库存	数量
10 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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纯度: 99.88%

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COA HNMR HPLC 产品操作手册

产品介绍

Z-Glycine AI Summary

Z-Glycine exhibits a range of biological activities and pharmacological effects. It demonstrates bioactivity in a papain-catalyzed hydrolysis assay with a Km value of 10,300 nM. Additionally, it shows significant anticonvulsant activity in various seizure models in mice, including maximal electroshock seizures and seizures induced by strychnine and 3-mercaptopropionic acid, suggesting its potential for managing neurological conditions associated with seizures. The compound also stimulates oxygen consumption activity of rat recombinant peptidylglycine alpha-amidating monooxygenase, with a Km value of 590,000 nM and a Vmax(app) value of 8.6/s, with a Vm(app) to Km(app) ratio of 1.5 x 10^4/M/s. Relative to hippuric acid, its activity is 2.4. In oncology studies, Z-Glycine exhibits antineoplastic activity against mouse EAC allografts in CF1 mice, significantly impacting packed cell volume and ascites volume, and achieving a high tumor growth inhibition rate of 97.0% on day 7 at a dose of 33 mg/kg. However, in the NAAA assay, the compound shows a weak or negligible inhibitory effect on N-acylethanolamine acid amidase (NAAA), with an IC50 value exceeding 100,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Z-Glycine (Carbobenzoxyglycine) is a drug-lipid conjugates designed to promote brain penetration based on its lipophilicity and resemblance to lipids in biological membranes[1].
别名	N-苄氧羰基-甘氨酸, N-Carbobenzoxyglycine, Carbobenzoxyglycine

化学信息

分子量	209.2
分子式	C₁₀H₁₁NO₄
CAS No.	1138-80-3
Smiles	OC(=O)CNC(=O)OCC1=CC=CC=C1
密度	1.2944 g/cm3 (Estimated)
颜色	White
物理性状	solid

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (262.91 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7801 mL	23.9006 mL	47.8011 mL	239.0057 mL
5 mM	0.9560 mL	4.7801 mL	9.5602 mL	47.8011 mL
10 mM	0.4780 mL	2.3901 mL	4.7801 mL	23.9006 mL
20 mM	0.2390 mL	1.1950 mL	2.3901 mL	11.9503 mL
50 mM	0.0956 mL	0.4780 mL	0.9560 mL	4.7801 mL
100 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL