Bisantrene

Name: Bisantrene
Brand: TargetMol
SKU: T4047
Price: 227 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.57%

货号 T4047Cas号 78186-34-2

别名 比生群, CL216942

Bisantrene (CL216942) 是一种具有抗肿瘤活性的蒽基双腙，可靶向作用于真核生物的 II 型拓扑异构酶。它插入并破坏 DNA 的构型，导致 DNA 单链断裂、DNA-蛋白质交联和 DNA 复制的抑制。

Bisantrene

一键复制产品信息

很棒

纯度: 98.57%

货号 T4047 别名 比生群, CL216942Cas号 78186-34-2

规格	价格	库存
5 mg	¥ 227	现货
10 mg	¥ 413	现货
25 mg	¥ 898	现货
50 mg	¥ 1,490	现货
100 mg	¥ 2,470	现货
200 mg	¥ 3,650	现货
500 mg	¥ 5,830	现货

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产品介绍

Bisantrene AI Summary

Bisantrene exhibits a significant range of bioactivities with promising antitumor effects. It demonstrates potent inhibitory activity against various human tumor cell lines, including myeloma, ovarian tumor, endometrial tumor, and colon tumor cells. The compound is effective in inhibiting DNA, RNA, and protein synthesis, indicating its broad-spectrum anti-tumor and anti-proliferative properties. It shows considerable binding affinity with a determined binding constant (K app) of 9.03 uM^-1 and a significant increase in the melting temperature (Delta Tm = 19.0 degrees C) of calf thymus DNA. The compound exhibits cytotoxicity against human ovarian cancer (A2780) and human promyelocytic leukemia (HL60) cell lines, with IC50 values of 340.0 nM and 300.0 nM, respectively. It also inhibits Topoisomerase II activity, with efficacy increasing at higher concentrations. In animal models, Bisantrene increases the median life span in P388 leukemia and B-16 melanoma, suggesting potential curative effects. It also performs effectively against other cancer models, showing high potency even in multidrug-resistant cell lines. Furthermore, Bisantrene demonstrates bacterial mutagenicity in various strains of Salmonella Typhimurium, and has shown moderate liver toxicity, with 4.0% of cases exhibiting hepatotoxicity and a peak frequency of 49.0% during clinical trials. The compound also inhibits human recombinant NQO1 (IC50 = 25000.0 nM) and interacts with various receptors and enzymes, including DRD1, SLC6A3, ACHE, among others, with varying degrees of affinity and inhibition. These bioactivities suggest that Bisantrene holds substantial promise as an anti-cancer agent while requiring careful monitoring for potential liver toxicity and mutagenicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Bisantrene (CL216942) is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.
别名	比生群, CL216942

化学信息

分子量	398.46
分子式	C₂₂H₂₂N₈
CAS No.	78186-34-2
Smiles	C1CN=C(N\N=C\c2c3ccccc3c(\C=N\NC3=NCCN3)c3ccccc23)N1
密度	1.41 g/cm3 (Predicted)
颜色	Orange
物理性状	Solid

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	H2O: 0.1 mg/mL (0.25 mM), Sonication and heating to 50℃ are recommended. DMSO: 1 mg/mL (2.51 mM), Sonication and heating to 80℃ are recommended.