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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Quinacrine analog 34

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纯度: 99.98%

货号 T35747Cas号 1411646-44-0

Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.

Quinacrine analog 34

Quinacrine analog 34

一键复制产品信息
Rating icon 很棒

纯度: 99.98%

货号 T35747Cas号 1411646-44-0

Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.

规格价格库存数量
500 μg
¥ 1,560
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1 mg
¥ 2,850
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5 mg
¥ 12,000
现货
10 mg
¥ 20,900
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纯度: 99.98%
颜色: 白色
性状: Solid
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产品介绍

生物活性
产品描述
Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.
化学信息
分子量358.91
分子式C20H27ClN4
CAS No.1411646-44-0
SmilesN(CCN1CCN(C)CC1)C=2C=3C(N=C4C2CCCC4)=CC(Cl)=CC3
储存&溶解度
存储
溶解度信息
DMSO: 10 mg/mL (27.86 mM), Sonication is recommended.
DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL (1.39 mM), Sonication is recommended.
Ethanol: 5 mg/mL (13.93 mM), Sonication is recommended.
DMF: 10 mg/mL (27.86 mM), Sonication is recommended.
溶液配制表
Ethanol/DMSO/DMF
1mg5mg10mg50mg
5 mM0.5572 mL2.7862 mL5.5724 mL27.8621 mL
10 mM0.2786 mL1.3931 mL2.7862 mL13.9311 mL
DMSO/DMF
1mg5mg10mg50mg
20 mM0.1393 mL0.6966 mL1.3931 mL6.9655 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Quinacrine analog 34
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