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Anthracene-9-carboxylic acid

Name: Anthracene-9-carboxylic acid
Brand: TargetMol
SKU: T8632
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.05%

货号 T8632Cas号 723-62-6

别名 9-蒽甲酸

Anthracene-9-carboxylic acid 是一种氯化物转运抑制剂，对 PKA 激活的心脏 IcI 具有中度至强的抑制作用。

Anthracene-9-carboxylic acid

一键复制产品信息

很棒

纯度: 99.05%

货号 T8632 别名 9-蒽甲酸Cas号 723-62-6

Anthracene-9-carboxylic acid 是一种氯化物转运抑制剂，对 PKA 激活的心脏 IcI 具有中度至强的抑制作用。

规格	价格	库存	数量
200 mg	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.05%

颜色: 白色

性状: solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Anthracene-9-carboxylic acid AI Summary

Anthracene-9-carboxylic acid exhibits a broad spectrum of bioactivities, acting as an inhibitor in various assays targeting multiple molecular interactions and enzymes. It demonstrates potent inhibition of the Menin-MLL interaction in MLL-related leukemias, HSD17B4, JMJD2E, Cytochrome P450 2C19, Aldehyde Dehydrogenase 1 (ALDH1A1), HPGD (15-Hydroxyprostaglandin Dehydrogenase), human alpha-Galactosidase, and USP1/UAF1. It also functions as a lipid storage modulator. The compound inhibits lactate uptake in Xenopus laevis oocytes with significant activity. In Caenorhabditis elegans N2 Bristol, it inhibits a voltage-gated calcium channel by 20.0% at 50 mg/l after 1 hour, and shows ovicidal activity against Meloidogyne incognita eggs, with an EC50 of 48.01 ug/mL. It has nematicidal activity against J2 juveniles and adult C. elegans N2 Bristol, with LC50 values ranging from 5.35 to 42.7 ug/mL. Additionally, it exhibits high inhibitory activity in OATP1B3 and OATP1B1-transfected CHO cells, showing 87.88% and 95.94% inhibition, respectively, in the uptake of sodium fluorescein at 10 uM. Regarding antiviral properties, Anthracene-9-carboxylic acid inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 5.36% at 10 uM after 48 hours, inhibits the SARS-CoV-2 3CL-Pro protease by 16.23% at 20 µM, and shows a 0.72% inhibition rate in VERO-6 cells at 10 uM after 48 hours of viral exposure. Finally, it shows inhibitory activity against human HDAC6 enzyme, with a 22.87% inhibition in an enzymatic assay using a commercial peptide substrate, though it exhibited a lower inhibition of -0.75% in a separate assay with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI.
别名	9-蒽甲酸

化学信息

分子量	222.24
分子式	C₁₅H₁₀O₂
CAS No.	723-62-6
Smiles	OC(=O)c1c2ccccc2cc2ccccc12
密度	1.305 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 22.22 mg/mL (99.98 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4996 mL	22.4982 mL	44.9964 mL	224.9820 mL
5 mM	0.8999 mL	4.4996 mL	8.9993 mL	44.9964 mL
10 mM	0.4500 mL	2.2498 mL	4.4996 mL	22.4982 mL
20 mM	0.2250 mL	1.1249 mL	2.2498 mL	11.2491 mL
50 mM	0.0900 mL	0.4500 mL	0.8999 mL	4.4996 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Cl-transport Anthracene-9-carboxylic acid Anthracene9carboxylic acid Anthracene 9 carboxylic acid

Anthracene-9-carboxylic acid

Anthracene-9-carboxylic acid