Tobramycin

Name: Tobramycin
Brand: TargetMol
SKU: T1255
Price: 187 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.87%

货号 T1255Cas号 32986-56-4

别名 妥布霉素, NSC 180514, Nebramycin Factor 6, Deoxykanamycin B

Tobramycin (NSC-180514) 是一种胃肠外给药的广谱氨基糖苷类抗生素，可研究由于敏感生物引起的中度至重度细菌感染疾病。

Tobramycin

一键复制产品信息

很棒

纯度: 99.87%

货号 T1255 别名 妥布霉素, NSC 180514, Nebramycin Factor 6, Deoxykanamycin BCas号 32986-56-4

Tobramycin (NSC-180514) 是一种胃肠外给药的广谱氨基糖苷类抗生素，可研究由于敏感生物引起的中度至重度细菌感染疾病。

规格	价格	库存
25 mg	¥ 187	现货
50 mg	¥ 259	现货
100 mg	¥ 372	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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产品介绍

Tobramycin AI Summary

Tobramycin exhibits broad-spectrum antibacterial activity against various bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, and Klebsiella pneumoniae, with Minimum Inhibitory Concentrations (MIC) ranging from as low as 0.03 µg/mL to greater than 512 µg/mL depending on the strain and conditions. Notably, it shows significant efficacy against multidrug-resistant strains, indicating its potential usefulness in treating challenging bacterial infections. Additionally, Tobramycin demonstrates specific binding affinities to RNA constructs, inhibiting protein synthesis and other critical bacterial processes, with dissociation constants (Kd) ranging widely from 0.9 nM to 41,430 nM for different RNA targets. It has also shown activity against the Rev-RBE RNA complex, mitochondrial 12S rRNA constructs, and demonstrated in vivo efficacy in mouse infection models. The compound manifests varying degrees of rapidity in its pharmacokinetic parameters, showing a quick absorption rate and substantial initial plasma concentrations. Lastly, while it exhibits promising antibacterial properties, its efficacy is reduced against certain resistant strains, and its activity against biofilms indicates potential utility in more complex bacterial growth scenarios..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tobramycin (NSC-180514) is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.
别名	妥布霉素, NSC 180514, Nebramycin Factor 6, Deoxykanamycin B

化学信息

分子量	467.51
分子式	C₁₈H₃₇N₅O₉
CAS No.	32986-56-4
Smiles	O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)C[C@H]2N)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
密度	1.52 g/cm3

储存&溶解度

存储

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 250 mg/mL (534.75 mM), Sonication is recommended.

DMSO: Insoluble

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1390 mL	10.6950 mL	21.3899 mL	106.9496 mL
5 mM	0.4278 mL	2.1390 mL	4.2780 mL	21.3899 mL
10 mM	0.2139 mL	1.0695 mL	2.1390 mL	10.6950 mL
20 mM	0.1069 mL	0.5347 mL	1.0695 mL	5.3475 mL
50 mM	0.0428 mL	0.2139 mL	0.4278 mL	2.1390 mL
100 mM	0.0214 mL	0.1069 mL	0.2139 mL	1.0695 mL