购物车

您的购物车当前为空

Tegobuvir

Name: Tegobuvir
Brand: TargetMol
SKU: T17029
Price: 752 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.21%

货号 T17029Cas号 1000787-75-6

别名 GS-9190, GS 333126, 5-[[6-[2,4-双(三氟甲基)苯基]-3-哒嗪基]甲基]-2-(2-氟苯基)-5H-咪唑并[4,5-C]吡啶

Tegobuvir (GS 333126) 是特异性共价的HCV NS5B 聚合酶抑制剂。

为众多的药物研发团队赋能，

让新药发现更简单！

Tegobuvir

一键复制产品信息

很棒

纯度: 99.21%

货号 T17029 别名 GS-9190, GS 333126, 5-[[6-[2,4-双(三氟甲基)苯基]-3-哒嗪基]甲基]-2-(2-氟苯基)-5H-咪唑并[4,5-C]吡啶Cas号 1000787-75-6

Tegobuvir (GS 333126) 是特异性共价的HCV NS5B 聚合酶抑制剂。

规格	价格	库存
1 mg	¥ 752	现货
5 mg	¥ 1,860	现货
10 mg	¥ 2,820	现货
25 mg	¥ 4,470	现货
50 mg	¥ 6,180	现货
100 mg	¥ 8,170	现货
1 mL x 10 mM (in DMSO)	¥ 2,120	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.21%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Tegobuvir AI Summary

Tegobuvir exhibits notable antiviral activity and enzyme inhibition properties. Specifically, it demonstrates potent antiviral efficacy against Hepatitis C virus (HCV) genotype 1b in human HuH5.2 cells with an EC50 of 0.7 nM after 72 hours, as assessed via a luciferase reporter gene assay. Additionally, it shows antiviral activity against HCV genotype 1b in human HuH7 cells with an EC50 of 5.0 nM after 48 hours and inhibits HCV genotype 1b NS5B RNA-dependent-RNA polymerase with an EC50 of approximately 2.908-2.9 nM. The compound also exhibits inhibitory effects on human ERG expressed in CHO cells with an IC50 of 794.33 nM, and it inhibits human HDAC6 enzyme activity by 24.72% using a commercial peptide substrate. Furthermore, Tegobuvir demonstrates antiviral effects against SARS-CoV-2, inhibiting the virus-induced cytotoxicity of Caco-2 cells at 10 µM after 48 hours with an inhibition rate of 4.14%. It also inhibits SARS-CoV-2 3CL-Pro protease activity at 20 µM with inhibition percentages of 7.92% and 7.017%. However, inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells was relatively minimal, with percentages of 0.18% and -0.23%..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tegobuvir (GS 333126) is a specific and covalent HCV NS5B polymerase inhibitor.
别名	GS-9190, GS 333126, 5-[[6-[2,4-双(三氟甲基)苯基]-3-哒嗪基]甲基]-2-(2-氟苯基)-5H-咪唑并[4,5-C]吡啶

化学信息

分子量	517.4
分子式	C₂₅H₁₄F₇N₅
CAS No.	1000787-75-6
Smiles	Fc1ccccc1-c1nc2ccn(Cc3ccc(nn3)-c3ccc(cc3C(F)(F)F)C(F)(F)F)cc2n1
密度	1.46 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (96.64 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.87 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9327 mL	9.6637 mL	19.3274 mL	96.6370 mL
5 mM	0.3865 mL	1.9327 mL	3.8655 mL	19.3274 mL
10 mM	0.1933 mL	0.9664 mL	1.9327 mL	9.6637 mL
20 mM	0.0966 mL	0.4832 mL	0.9664 mL	4.8319 mL
50 mM	0.0387 mL	0.1933 mL	0.3865 mL	1.9327 mL