Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2B receptors, with respective potency values of EC 50 = 32 μM and IC 50 = 27 μM. Its primary mechanism of action involves the modulation of serotonergic and noradrenergic pathways. Viloxazine is commonly employed in depression research [1] [2].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,300 | 现货 | ||
5 mg | ¥ 2,900 | 现货 | ||
10 mg | ¥ 4,290 | 现货 | ||
25 mg | ¥ 6,850 | 现货 | ||
50 mg | ¥ 9,270 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
500 mg | ¥ 24,800 | 现货 |
产品描述 | Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2B receptors, with respective potency values of EC 50 = 32 μM and IC 50 = 27 μM. Its primary mechanism of action involves the modulation of serotonergic and noradrenergic pathways. Viloxazine is commonly employed in depression research [1] [2]. |
靶点活性 | 5-HT2B:27 μM, 5-HT2C:32 μM(EC50) |
体内活性 | Viloxazine (1-16 mg/kg; spinal rat) stimulated the hind limb flexor reflex in the dose-dependent manner.[3] |
别名 | Emovit, Viloxazin |
分子量 | 237.29 |
分子式 | C13H19NO3 |
CAS No. | 46817-91-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (252.86 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.2143 mL | 21.0713 mL | 42.1425 mL | 105.3563 mL |
5 mM | 0.8429 mL | 4.2143 mL | 8.4285 mL | 21.0713 mL | |
10 mM | 0.4214 mL | 2.1071 mL | 4.2143 mL | 10.5356 mL | |
20 mM | 0.2107 mL | 1.0536 mL | 2.1071 mL | 5.2678 mL | |
50 mM | 0.0843 mL | 0.4214 mL | 0.8429 mL | 2.1071 mL | |
100 mM | 0.0421 mL | 0.2107 mL | 0.4214 mL | 1.0536 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Viloxazine 46817-91-8 GPCR/G Protein Neuroscience 5-HT Receptor Norepinephrine Emovit Viloxazin Inhibitor inhibitor inhibit