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Dipyridamole

Name: Dipyridamole
Brand: TargetMol
SKU: T1618
Price: 118 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 T1618Cas号 58-32-2

别名 双嘧达莫, Persantin, NSC-515776, Dypyridamole, Dipyudamine, Dipyridamol

Dipyridamole (Persantin) 是一种磷酸二酯酶抑制剂，能阻断红细胞和血管内皮细胞对腺苷的吸收和代谢。

Dipyridamole

一键复制产品信息

很棒

纯度: 99.84%

货号 T1618 别名 双嘧达莫, Persantin, NSC-515776, Dypyridamole, Dipyudamine, DipyridamolCas号 58-32-2

Dipyridamole (Persantin) 是一种磷酸二酯酶抑制剂，能阻断红细胞和血管内皮细胞对腺苷的吸收和代谢。

规格	价格	库存
10 mg	¥ 118	现货
25 mg	¥ 169	现货
50 mg	¥ 232	现货
100 mg	¥ 325	现货
500 mg	¥ 535	现货
1 mL x 10 mM (in DMSO)	¥ 132	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.84%

颜色: 黄色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Dipyridamole AI Summary

Dipyridamole is a multifunctional inhibitor displaying significant bioactivity across a range of targets. It primarily inhibits Phosphodiesterase 4 (PDE4) from guinea pig macrophages with an IC50 value of 500.0 nM and exhibits a range of inhibitory effects on [3H]thymidine uptake in L1210 cells, showing 80.0%-99.0% inhibition at both 1 μM and 10 μM concentrations, and retains significant activity even in the presence of alpha1-acid glycoprotein (AGP). Additionally, Dipyridamole demonstrates notable inhibitory action on several human phosphodiesterases (PDEs) with mixed potencies: it is most effective against PDE1, PDE2, PDE3, PDE4, and PDE5, with varying IC50 values. It also shows significant inhibition of nucleoside transporters, particularly human ENT1 and ENT2, with IC50 values as low as 8.1 nM for ENT1. In terms of antithrombosis, Dipyridamole has effective doses (ED50) of 142.69 μmol/kg and 72.0 mg/kg in mice. It shows mild inhibition of Batrachotoxinin [3H]BTX-B binding to sodium channels in guinea pig cerebral cortex. Furthermore, Dipyridamole has bioactivity against several malaria strains, especially Plasmodium falciparum 7G8, with IC50 values indicating substantial antiplasmodial effects. In viral studies, it has demonstrated limited antiviral activity against SARS-CoV-2. The compound exhibits transporter inhibition, demonstrating influence on P-glycoprotein, MRP, and various organic cation transporters (OCTs), and shows multidrug resistance modulation properties. It also affects hepatic and renal function markers, suggesting a moderate risk for liver toxicity. Finally, Dipyridamole indicates cytotoxicity towards certain cancer cell lines and exhibits potential in reducing cell proliferation and inducing autophagy. Overall, Dipyridamole is a potent and versatile compound with broad pharmacological profiles, making it a promising candidate for therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.
别名	双嘧达莫, Persantin, NSC-515776, Dypyridamole, Dipyudamine, Dipyridamol

化学信息

分子量	504.63
分子式	C₂₄H₄₀N₈O₄
CAS No.	58-32-2
Smiles	N(CCO)(CCO)C1=NC2=C(C(=N1)N3CCCCC3)N=C(N(CCO)CCO)N=C2N4CCCCC4
密度	1.352 g/cm3

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (495.41 mM), Sonication is recommended.

Ethanol: 47 mg/mL (93.14 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.54 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9816 mL	9.9082 mL	19.8165 mL	99.0825 mL
5 mM	0.3963 mL	1.9816 mL	3.9633 mL	19.8165 mL
10 mM	0.1982 mL	0.9908 mL	1.9816 mL	9.9082 mL
20 mM	0.0991 mL	0.4954 mL	0.9908 mL	4.9541 mL
50 mM	0.0396 mL	0.1982 mL	0.3963 mL	1.9816 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.9908 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

phosphodiesterase (PDE) inhibitor Phosphodiesterase (PDE)phosphodiesterase PDE NSC515776 NSC 515776 Inhibitor inhibit Dipyridamole cancer antiplatelet

Dipyridamole

Dipyridamole

Dipyridamole 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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