GSK3368715

Name: GSK3368715
Brand: TargetMol
SKU: T11500
Rating: 4.5 (1 reviews)

还可以

产品编号 T11500Cas号 1629013-22-4

别名 EPZ019997

GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). It has strong anti-cancer activity.

GSK3368715

还可以

产品编号 T11500 别名 EPZ019997Cas号 1629013-22-4

规格	价格	库存
25 mg	待询	3-6月
50 mg	待询	3-6月
100 mg	待询	3-6月

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GSK3368715 相关产品

产品介绍

生物活性

产品描述	GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). It has strong anti-cancer activity.
靶点活性	PRMT8:1.7 nM , PRMT4:1148 nM , PRMT1:3.1 nM , PRMT6:5.7 nM , PRMT3:48 nM
体外活性	GSK3368715 ?shows 50% or more growth inhibition relative to DMSO-treated cells in the majority of 249 cancer cell lines, representing 12 tumor types.
体内活性	GSK3368715 significantly effects on the growth of BxPC3 xenografts at all doses tested, reducing tumor growth by 78% and 97% in the 150- and 300-mg/kg dose groups, respectively.
别名	EPZ019997