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Cefpiramide acid

Name: Cefpiramide acid
Brand: TargetMol
SKU: T0138
Price: 192 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 97.40%

货号 T0138Cas号 70797-11-4

别名 头孢匹胺, Cefpiramidum, Cefpiramido

Cefpiramide acid (Cefpiramidum) 是第三代头孢菌素类抗生素。

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Cefpiramide acid

一键复制产品信息

很棒

纯度: 97.40%

货号 T0138 别名 头孢匹胺, Cefpiramidum, CefpiramidoCas号 70797-11-4

Cefpiramide acid (Cefpiramidum) 是第三代头孢菌素类抗生素。

规格	价格	库存
5 mg	¥ 192	现货
10 mg	¥ 336	现货
25 mg	¥ 664	现货
50 mg	¥ 1,064	现货
100 mg	¥ 1,383	现货
200 mg	¥ 1,952	现货
1 mL x 10 mM (in DMSO)	¥ 294	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

生物活性

产品描述	Cefpiramide acid (Cefpiramidum) is a third-generation cephalosporin antibiotic.
别名	头孢匹胺, Cefpiramidum, Cefpiramido

化学信息

分子量	612.64
分子式	C₂₅H₂₄N₈O₇S₂
CAS No.	70797-11-4
Smiles	[H][C@]12SCC(CSc3nnnn3C)=C(N1C(=O)[C@H]2NC(=O)[C@H](NC(=O)c1cnc(C)cc1O)c1ccc(O)cc1)C(O)=O
密度	1.75 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.5 mg/mL (44.89 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6323 mL	8.1614 mL	16.3228 mL	81.6140 mL
5 mM	0.3265 mL	1.6323 mL	3.2646 mL	16.3228 mL
10 mM	0.1632 mL	0.8161 mL	1.6323 mL	8.1614 mL
20 mM	0.0816 mL	0.4081 mL	0.8161 mL	4.0807 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Cefpiramide acid is a multi-functional compound exhibiting diverse bioactivities across several contexts. It shows species-dependent pharmacokinetics with varying volumes of distribution and clearance rates; notably, it has a lower volume of distribution and clearance in humans and monkeys compared to rats and dogs. As a potent inhibitor of the vitamin D receptor (VDR) with a potency of 39810.7 nM, Cefpiramide acid also demonstrates significant delayed death inhibition of the malarial parasite plastid, exhibiting a potency of 13459.1 nM after 96 hours. The compound demonstrates moderate liver toxicity with hepatotoxic effects observed in clinical trials, manifesting as acute and cytolytic liver toxicity without indications of severe hepatitis or chronic liver disease. In addition, Cefpiramide acid possesses potent antibacterial properties, particularly against tolC-deficient Escherichia coli (MIC of 0.5 ug.mL-1) and demonstrates activity against wild-type Staphylococcus aureus with a MIC of 32.0 ug.mL-1, which increases in the presence of human serum albumin (HSA). Bioactivity studies also indicate its involvement in hepatic drug metabolism, excretion, and clearance processes in human, dog, and rat models. Notably, the compound has a low fraction unbound in human plasma (0.09%) compared to dog plasma (0.6%), highlighting differences in binding affinity or bioavailability across species. While showing moderate inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2, its antiviral activity against the SARS-CoV-2 USA-WA1/2020 strain is below the hit threshold. Furthermore, Cefpiramide acid exhibits inhibition of the human HDAC6 enzyme, with differing inhibition percentages depending on the assay substrate used. Overall, Cefpiramide acid showcases a range of bioactivities from antibacterial and antiviral properties to liver toxicity and enzyme inhibition, dependent on the context and specific biological system evaluated..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl