规格

价格

库存

数量

10 mg

¥ 289

现货

50 mg

¥ 996

现货

100 mg

¥ 1,692

现货

200 mg

¥ 2,538

现货

1 mL x 10 mM (in DMSO)

¥ 327

现货

生物活性

产品描述	Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.
靶点活性	Adenosine deaminase (U266 cells):2.43 μM, Adenosine deaminase (MM1.S cells):0.18 μM, Adenosine deaminase (RPMI8226 cells):0.75 μM
体外活性	在成年斑马鱼中,腹腔注射Cladribine（0.7-3.5 mM ）,能够抑制RBC ATP浓度水平.
体内活性	在原代肥大细胞（MC）和MC系HMC-1中,Cladribine抑制细胞生长。在CD14 +单核细胞以及CD4 +和CD8 + T淋巴细胞中,Cladribine降低细胞迁移能力。在U266,RPMI8226和MM1.S细胞中,Cladribine以剂量依赖性方式抑制细胞增殖。
细胞实验	The non-radioactive cell proliferation kit is used to determine cell viability. In brief, Human MM cell line U266, RPMI8226 and MM1.S are seeded onto 96-well plates with either 0.1 mL complete medium (5% FBS) as control, or 0.1 mL of the same medium containing a series of doses of cladribine, and incubated for 72 hours. After reading all wells at 490 nm with a micro-plate reader, the percentages of surviving cells from each group relative to controls, defined as 100% survival, are determined by reduction of MTS.(Only for Reference)
别名	克拉屈滨, CldAdo, 2-chlorodeoxyadenosine, 2-Chloro-2′-deoxyadenosine, 2CdA

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 255 mg/mL (892.58 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (17.5 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO