IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.

CK1δ:0.56 μM (Kd), MKNK2:1.2 μM (Kd), JNK2:290 nM(Kd), JNK3:66 nM(Kd), PI3Kγ:0.43 μM (Kd), JNK1:240 nM(Kd)