Name: TAT-DEF-Elk-1
Brand: TargetMol
SKU: TP2157
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

100 mg

待询

500 mg

待询

生物活性

产品描述	TAT-DEF-Elk-1 is a synthetic penetrating peptide designed to specifically interfere with the DEF docking domain of the transcription factor Elk-1, blocking its ERK-dependent nuclear translocation. By preventing Elk-1 phosphorylation on Ser383/389, the peptide inhibits both nuclear relocalization and SRE-dependent gene expression without disrupting ERK or MSK1 activation. This compound is used in research to study cytonuclear trafficking, dendritic elongation, and cytoskeleton dynamics, including the regulation of SRF and actin expression in neuronal models.
靶点活性 (IC₅₀)	ELK1:
体外活性	Elk-1 phosphorylation on Ser383/389 simultaneously induces Elk-1 nuclear translocation and SRE-dependent gene expression. TAT-DEF-Elk-1 (5 μM for 2 hours) significantly inhibits c-Fos, Zif268, and JunB without affecting c-Jun expression. Additionally, TAT-DEF-Elk-1 (5-10 μM for 1 hour) specifically inhibits glutamate-induced Elk-1 activation without interfering with ERK, MSK-1, or CREB phosphorylation ^[1].
体内活性	TAT-DEF-Elk-1 (i.p.; 1mg/kg; daily; 14 days) reflects antidepressant efficacy in mice, it decreases immobility similar to the antidepressant desipramine and fluoxetine ^[2].
别名	TDE

化学信息

分子量	3561.136
分子式	C₁₅₅H₂₅₉N₅₇O₄₀
CAS No.	1220751-16-5
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(C)C)C(O)=O
密度	1.53 g/cm3 (Predicted)
Sequence	H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Ser-Pro-Ala-Lys-Leu-Ser-Phe-Gln-Phe-Pro-Ser-Ser-Gly-Ser-Ala-Gln-Val-His-Ile-OH
Sequence Short	GRKKRRQRRRPPSPAKLSFQFPSSGSAQVHI

储存&溶解度

存储	Keep away from direct sunlight,Keep away from moisture,Store under nitrogen, Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

TAT-DEF-Elk-1