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Tyrphostin AG 528

Name: Tyrphostin AG 528
Brand: TargetMol
SKU: T4528
Price: 185 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.64%

货号 T4528Cas号 133550-49-9

别名 Tyrphostin B66, AG 528

Tyrphostin AG 528 (Tyrphostin B66) 是一种蛋白酪氨酸激酶抑制剂，对表皮生长因子受体 (EGFR) 的IC50为 4.9 μM，对ErbB2的IC50为 2.1 μM，具有抗癌作用。

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Tyrphostin AG 528

一键复制产品信息

很棒

纯度: 99.64%

货号 T4528 别名 Tyrphostin B66, AG 528Cas号 133550-49-9

Tyrphostin AG 528 (Tyrphostin B66) 是一种蛋白酪氨酸激酶抑制剂，对表皮生长因子受体 (EGFR) 的IC50为 4.9 μM，对ErbB2的IC50为 2.1 μM，具有抗癌作用。

规格	价格	库存
1 mg	¥ 185	现货
5 mg	¥ 398	现货
10 mg	¥ 689	现货
25 mg	¥ 1,380	现货
50 mg	¥ 2,320	现货
100 mg	¥ 3,560	现货
200 mg	¥ 5,130	现货
1 mL x 10 mM (in DMSO)	¥ 398	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.64%

颜色: 黄色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Tyrphostin AG 528 AI Summary

Tyrphostin AG 528 exhibits a wide range of bioactivities, including significant inhibitory effects against key proteins involved in cancer and infectious diseases. It has shown inhibitory activity against epidermal growth factor receptor (EGFR) with an IC50 value of 12022.64 nM and against protein kinase HER-2 with an IC50 value of 4897.79 nM, suggesting its potential as a targeted therapy for cancers driven by EGFR and HER-2 signaling pathways. Additionally, it inhibits polyGAT phosphorylation, HER1 and ERBB2 autophosphorylation, and HER14 cell proliferation without EGF. In the field of infectious diseases, Tyrphostin AG 528 demonstrates antiplasmodial activity against Plasmodium falciparum with IC50 values ranging from 2511.89 nM to 15848.93 nM, indicating its potential in treating malaria. It also exhibits antiviral properties, including inhibition of the SARS-CoV-2 3CL-Pro protease by 5.9% at 20 µM and reducing SARS-CoV-2 induced cytotoxicity in VERO-6 cells by 0.53% at 10 µM for 48 hours. Furthermore, Tyrphostin AG 528 inhibits various other bioactivities such as ATPase activity of Tag, L3MBTL1, JMJD2A-Tudor Domain, GCN5L2, SV40 T antigen, and Histone Lysine Methyltransferase G9a. It also exhibits inhibitory actions on polymerases Iota and Eta, Flap endonuclease 1 (FEN1), TGF-b, WRN Helicase, Pin1, tyrosyl-DNA phosphodiesterase 1 (TDP1), and induces DNA re-replication in cancer cells. Additionally, it displays potential for antimalarial drug development by inhibiting AMA1-RON and shows activity against the SARS-CoV-2 virus. These diverse bioactivities make Tyrphostin AG 528 a promising candidate for further investigation in oncology, infectious diseases, and other therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).
靶点活性	EGFR:4.9 μM, ErbB2:2.1 μM
别名	Tyrphostin B66, AG 528

化学信息

分子量	306.32
分子式	C₁₈H₁₄N₂O₃
CAS No.	133550-49-9
Smiles	Oc1ccc(\C=C(\C#N)C(=O)N2CCc3ccccc23)cc1O
密度	1.416 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (179.55 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.53 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2646 mL	16.3228 mL	32.6456 mL	163.2280 mL
5 mM	0.6529 mL	3.2646 mL	6.5291 mL	32.6456 mL
10 mM	0.3265 mL	1.6323 mL	3.2646 mL	16.3228 mL
20 mM	0.1632 mL	0.8161 mL	1.6323 mL	8.1614 mL
50 mM	0.0653 mL	0.3265 mL	0.6529 mL	3.2646 mL
100 mM	0.0326 mL	0.1632 mL	0.3265 mL	1.6323 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。