store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SM1-71 是一种有效的多靶点丙烯酰胺修饰的 TAK1 抑制剂,抑制 MKNK2、MAP2K1/2/3/4/6/7、GAK、AAK1、BMP2K、MAP3K7、MAPKAPK5、GSK3A/B、MAPK1/3、SRC、YES1、FGFR1、ZAK (MLTK)、MAP3K1、LIMK1 和 RSK2。SM1-71 可作为激酶探针,具有抗癌活性,抑制多种癌细胞系的增殖。
产品描述 | SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-71 can be used as a kinase probe with anticancer activity and inhibits the proliferation of various cancer cell lines. |
靶点活性 | GAK:0.8 nM, MAPK3:107 nM, SRC:2 nM, MAPK1:48.3 nM, MAP3K1:28.7 nM, MAP2K1:10.4 nM, LIMK1:5.4 nM, YES1:0.8 nM, BMP2K:7.1 nM, MAP2K2:9.3 nM, AAK1:4.4 nM |
体外活性 | Potently inhibiting the proliferation of H23 and Calu-6 non-small cell lung cancer cell lines in a concentration-dependent manner, SM1-71 (0.001-100 μM; 72 h) demonstrates its efficacy. Additionally, SM1-71 induces potent cytotoxicity within 72 hours, with nanomolar values for GR50 and negative GRmax values observed in eight of 11 cancer cell lines[1][2]. |
分子量 | 463.96 |
分子式 | C24H26ClN7O |
CAS No. | 2088179-99-9 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (215.54 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1554 mL | 10.7768 mL | 21.5536 mL | 53.884 mL |
5 mM | 0.4311 mL | 2.1554 mL | 4.3107 mL | 10.7768 mL | |
10 mM | 0.2155 mL | 1.0777 mL | 2.1554 mL | 5.3884 mL | |
20 mM | 0.1078 mL | 0.5388 mL | 1.0777 mL | 2.6942 mL | |
50 mM | 0.0431 mL | 0.2155 mL | 0.4311 mL | 1.0777 mL | |
100 mM | 0.0216 mL | 0.1078 mL | 0.2155 mL | 0.5388 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SM1-71 2088179-99-9 Cell Cycle/Checkpoint MAPK Metabolism Neuroscience Stem Cells Serine/threonin kinase LIM Kinase TGF-beta/Smad AAK1 (AP2 associated kinase 1) SM-1-71 SM171 SM1 71 Inhibitor inhibitor inhibit